Abstract: Objective To explore the risk factors of asymptomatic gallbladder stones secondary to common bile duct stones.Methods  A retrospective analysis was conducted on the data of asymptomatic gallstone patients diagnosed by the physical examination center of our hospital from January 2019 to October 2021,as well as asymptomatic gallstone patients with secondary common bile duct stones admitted to the hospital.According to whether secondary common bile duct stones occurred,the patients were divided into two groups.Among them,134 patients with asymptomatic gallbladder stones were the control group.There were 150 cases of common bile duct stones secondary to asymptomatic gallbladder stones,which were the observation group.The differences in baseline data between the two studies were balanced by propensity match scoring.The relevant data were compared and analyzed.Statistical analysis of the data was performed using SPSS 26.0 software and R software.Results  There was no statistical significance in the distribution of age,gender,BMI index,smoking,drinking,exercise,hypertension and diabetes between the two groups (P>0.05).The comparison of clinical indicators between groups showed that the number of gallbladder stones (multiple),the maximum diameter of stones (≥ 10mm),and the diameter of the common bile duct may be related to asymptomatic gallbladder stones secondary to common bile duct stones,with pvalues all less than 0.05 and statistically significant differences.There were statistically significant differences in the number of gallbladder stones (multiple),the maximum diameter of the stones (≥10mm),and the diameter of the common bile duct (P<0.05).Youdaoplaceholder0 Logistic Multivariate regression analysis showed that OR of the maximum diameter of the stone was 0.362(0.181-0.725),which was a protective factor for common bile duct stones secondary to asymptomatic gallbladder stones,and OR of the common bile duct diameter was 2.076(1.571-2.743),which was a risk factor for common bile duct stones secondary to asymptomatic gallbladder stones.Conclusion  Asymptomatic gallbladder stones secondary to common bile duct stones are the result of multiple factors working together.

Key words: asymptomatic gallstones, choledocholithiasis, risk factors, complications