Abstract: Objective To investigate the correlation between serum nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) level and cerebral blood supply and prognosis in patients with aneurysm al subarachnoid hemorrhage (aSAH).Methods 150 patients with aSAH admitted to our hospital from January 2021 to December 2023 were selected retrospectively as the observation group (150 cases),and 65 healthy people in our hospital were selected as the control group (65 cases) during the same period.Pearson correlation coefficient was used to analyze the correlation between serum NOX2 level and blood flow velocity of middle cerebral artery (MCA) and anterior cerebral artery (ACA).After 90 days of follow-up,according to the prognosis of aSAH patients,they were divided into good prognosis group (98 cases) and poor prognosis group (52 cases).Multivariate Logistic regression was used to analyze the related factors of poor prognosis in aSAH patients,and ROC curve was drawn to analyze the predictive efficacy of related factors.Results The serum NOX2 of the observation group and the control group were (2 185.20±231.15)pg/ml and (1 025.31±98.24)pg/ml,the Vm of MCA was (64.30±8.22)cm/s and (89.16±9.14)cm/s,and the Vm of ACA was (39.20±3.04)cm/s and (51.03±9.35)cm/s,respectively.The difference between the two groups was statistically significant(P<0.05).Pearson correlation coefficient analysis showed that the serum NOX2 level of aSAH patients was negatively correlated with the Vm of MCA and ACA (r=-0.512/-0.219,P<0.05).The WBC of the poor prognosis group and the good prognosis group were (9.96±2.76)×10⁹/L and (8.35±2.51)×10⁹/L,the blood sugar level was (8.16±2.05)mmol/L and (7.18±1.89)mmol/L,the NOX2 level was (2 278.30±215.26)pg/ml and (1 985.36±221.34)pg/ml,the improved Fisher score was (3.02±0.98) and (2.12±0.61),the WFNS score was (4.01±0.84) and (2.16±0.72),and the proportion of acute hydrocephalus was 25.00% and 9.18%,respectively.The difference between the two groups was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that NOX2 level (OR=1.008) and improved Fisher score (OR=6.329) were independent risk factors for poor prognosis of aSAH patients (P<0.05).The ROC curve shows that the NOX2 level and the area under curve (AUC) of the improved Fisher score are 0.844 (95%CI: 0.776~0.898) and 0.691 (95%CI: 0.611~0.764) respectively.Conclusion aSAH patients have higher serum NOX2 level,which is closely related to the blood supply of brain tissue.Serum NOX2 level and improved Fisher score are independent risk factors for poor prognosis of patients with aSAH,and serum NOX2 level has better predictive efficacy,which needs to be used as an effective index to predict poor prognosis of patients with aSAH.

Key words: nicotinamide adenine dinucleotide phosphate oxidase 2, aneurysmal subarachnoid hemorrhage, prognosis, blood supply of brain tissue