Abstract: Objective To explore the predictive value of D-dimer (D-D)/platelet count (PLT) ratio (DPR) for lower extremity deep vein thrombosis (DVT) after radical resection of colon cancer.Methods The clinical data of 366 cases who underwent radical resection of colon cancer in our hospital from January 2021 to December 2023 were selected and divided into DVT group (n=63) and non-DVT group (n=303) according to the presence or absence of lower extremity DVT after colon cancer surgery.The clinical data of all subjects were collected and the DPR at admission was calculated.The predictive value of DPR for lower extremity DVT after radical resection of colon cancer was evaluated by ROC.The influencing factors of lower extremity DVT after radical resection of colon cancer were explored by multivariate Logistic stepwise regression analysis.Results D-D and DPR in DVT group were higher than those in non-DVT group,PLT was lower than that in non-DVT group (P<0.05).ROC analysis showed that the AUC (95%CI) of D-D,PLT and DPR in predicting lower extremity DVT after radical resection of colon cancer were 0.811(0.762~0.853),0.723(0.675~0.770),0.919(0.872~0.969),respectively.Preoperative adjuvant chemotherapy,operation time > 3 h,postoperative continuous bed time > 2 d,and blood transfusion history were significantly higher in the DVT group than in the non-DVT group (P<0.05).Operation time > 3 h (OR=2.347,95%CI:1.424~3.868),history of blood transfusion (OR=1.937,95%CI:1.217~3.082),DPR≥0.60 (OR=4.707,95%CI:2.099~10.554) were risk factors for lower extremity DVT after radical resection of colon cancer (P<0.05).Conclusion DPR has significant predictive value in predicting the risk of lower extremity DVT after radical resection of colon cancer.It is an effective preoperative evaluation index.

Key words: colon cancer radical resection, Deep venous thrombosis of the lower extremity, D-dimer/platelet count ratio, predictive value