Abstract: Objective:To study the joint mesangial thyroid resection in the application of thyroid cancer radical.Methods:A prospective study of hospitalized in our department of 17 patients with thyroid cancer，using joint mesangial block resection of thyroid，statistics postoperative complications（bleeding，low calcium convulsions，voice hoarse，choking cough），number of lymph node cleaning，laryngeal recurrent nerve and protection，parathyroid gland，parathyroid hormone reduce，etc.，to evaluate the safety and clinical efficacy.Results:17 patients had smooth operation，16 cases of papillary carcinoma and 1 case of follicular carcinoma.The recurrent laryngeal nerve was revealed all the way after the free film in the operation，without injury.A total of 29 parathyroid glands of A1 and A2 were identified.Six B1 parathyroid glands were isolated and pathologically confirmed in the film.The average number of lymph nodes was 5.6±2.1，and the positive lymph node was 3.3±1.2.Intraoperative hemorrhage was（28.0±5.6）ml，and the incision drainage fluid was（34.0±7.6）ml.No hoarseness and cough were observed after the operation.There were 2 cases of temporary parathyroid hormone reduction after operation，and normal after calcium supplementation，and no permanent parathyroid hormone decreased.Conclusion:Thyroid joint mesangial block resection，can quickly and show all the laryngeal recurrent nerve，prevent damage；Can be more thoroughly cleaning the lymph node in central region，effectively protect the parathyroid gland；Surgery is safe，effective，reduce the operation difficulty，improve the quality of operation，more in line with the whole piece of tumor resection and diseasefree contact principle.

Key words: thyroid cancer, mesangial, ecurrent laryngeal nerve, parathyroid gland