Abstract:   Objective    To study the Cajal interstitial cells of gallbladder tissue in patients with cholecystolithiasis.Methods  The subjects were 103 patients with indirect cholecystectomy were divided into gallstone group（54 cases）and nongallstone group（49 cases）according to the existence of gallstone.The gallbladder contraction rate was calculated at 45min.The gallbladder tissue was excised as a specimen during the operation，and the neck，body and bottom tissues were sectioned respectively，the length was 0.2cm，0.5cm，0.8cm，respectively.The number of ICC was determined by immunofluorescence method.Results  The rate of gallbladder contraction and the number of ICC in gallstone group were significantly lower than those in noncholelithiasis group（P<0.05）.The rate of gallbladder contraction was positively correlated with the number of ICC in gallbladder tissue（r=0.137，P>0.05）.Conclusion  The number of ICC in gallbladder tissue of patients with gallstone was significantly decreased and the contraction function of gallbladder was decreased.However，there is not a simple linear relationship between the two factors，and there are other reasons for the effect of gallbladder contraction function，which can be used as a new direction in the treatment of cholecystolithiasis.

Key words: cholecystolithiasis, Cajal interstitial cell, contractile function, correlation