Abstract: Objective To investigate the outcomes and influencing factors of new-onset cerebral infarction after stent-assisted coil embolization for single intracranial aneurysms with Hunt-Hess grade 0-2.Methods A total of 116 patients with single intracranial aneurysms (Hunt-Hess grade 0-2) who underwent stent-assisted coil embolization and developed postoperative cerebral infarction in our hospital from January 2020 to January 2024 were selected as the research objects.Clinical outcomes were evaluated using the modified Rankin Scale (mRS) score after 1 year of follow-up: an mRS score < 3 indicated a good prognosis, while an mRS score ≥ 3 indicated a poor prognosis.Basic patient data were collected, and Logistic regression analysis was used to identify risk factors for poor prognosis of postoperative cerebral infarction.A nomogram prediction model was constructed, and the fitting effect of the model was evaluated.Results During the study period, a total of 813 cases of cerebral aneurysm treated with interventional therapy were admitted, among which 116 patients developed new-onset cerebral infarction after surgery.The proportion of aneurysm rupture was significantly higher in patients with cerebral infarction, and the difference was statistically significant (χ2=13.016, P＜0.001).Among the 116 patients with new-onset postoperative cerebral infarction, 23 (19.83%) had a poor prognosis.Logistic regression analysis showed that female gender, increased Hunt-Hess grade, prolonged operation time, irregular aneurysm, increased cerebral infarction volume, and intraoperative aneurysm rupture were independent risk factors for poor prognosis of postoperative cerebral infarction (P<0.05).The calibration curve showed that the corrected curve predicted by this model was close to the ideal curve.Conclusion Gender, Hunt-Hess grade, operation time, irregular aneurysm, cerebral infarction volume and intraoperative aneurysm rupture will affect the clinical outcomes of patients with new-onset cerebral infarction after stent-assisted coil embolization for single intracranial aneurysms with Hunt-Hess grade 0-2.

Key words: single intracranial aneurysm; stent-assisted coil embolization; cerebral infarction; poor prognosis