Abstract: Objective To conduct a bibliometric and visual analysis of the literature on targeted therapy for diabetic wounds over the past two decades,exploring research trends and hotspots in this field.Methods Literature on targeted therapy for diabetic wounds published between June 1,2005,and June 1,2025,was retrieved from the Web of Science Core Collection database.VOSviewer and CiteSpace software were used to perform visual analyses of publication trends,countries/regions,research institutions,journal distributions,author influence,and key words co-occurrence.Results A total of 605 articles were included.The annual publication volume in the field of targeted therapy for diabetic wounds generally showed an upward trend and is expected to continue increasing in the future.The country/region with the highest number of publications and total citations was China.The institution with the highest number of publications was Sun Yat-sen University.The journal with the highest number of publications was Diabetes.The author with the highest number of publications was Fu XB.Keyword co-occurrence cluster analysis indicated that research hotspots primarily focused on angiogenesis,inflammation,oxidative stress,diabetic foot ulcers,etc.Conclusion Research interest in targeted therapy for diabetic wounds continues to grow,with current studies mainly concentrated in basic research.Future efforts should foster inter-institutional collaboration across regions to enhance research quality and expedite the translation of basic research findings into clinical applications.

Key words: diabetic wounds; targeted therapy; bibliometrics; visual analysis; research hotspots