Abstract: Drug therapy is the main treatment for advanced gastrointestinal stromal tumors.Tyrosine kinase inhibitors targeting KIT/PDGFRA have significant efficacy.However, the problem of primary/induced drug resistance has promoted the development of new drugs to improve the treatment effect of the disease, and drugs with new targets/mechanisms of action are also being developed continuously.This article provides an overview of the recent progress in drug therapy research in this field.

Key words: gastrointestinal stromal tumors； drug therapy； research progress