Abstract: Objective To observe the clinical efficacy of continuous negative pressure closed drainage technology in promoting wound healing after anal fistula surgery.Methods From June 2022 to December 2024,60 patients with anal fistula and surgery admitted to our proctology department were randomly divided into an experimental group (30 cases) using continuous negative pressure closure drainage technology and a control group (30 cases) not using continuous negative pressure closure drainage technology.All patients underwent anal fistula resection surgery.Compare the clinical efficacy,wound healing rate,preoperative and postoperative inflammatory indicators [prostaglandin E2 (PGE2),high-sensitivity C-reactive protein (hs CRP),interleukin-6 (IL)],and wound healing time between the two groups.Results The postoperative experimental group had a wound area of (14.5±2.3) cm²,while the control group had a wound area of （12.8±3.6) cm².The observation course was 10 weeks.There was no statistically significant difference in age,disease duration,disease complexity,preoperative related examinations,postoperative wound area,and other data between the two groups of patients（P>0.05）.The effective rates of treatment in both groups were 100%.The wound healing rates of the experimental group at 2,3,6,and 10 weeks after surgery were (30.69±1.14)%,(45.59±3.25)%,(87.32±1.93)% and (100.00±0.00)%,respectively,while those of the control group were (15.78±0.15)%,(26.12±1.01)%,(65.31±0.32)% and (95.29±0.29)%,respectively.The difference between the two groups was statistically significant (P<0.05).On the third day after surgery,the experimental group had PGE2 levels of (142.13±12.85) ng/L,hs CRP levels of (8.13±0.92) ng/L,and IL-6 levels of (10.19±0.89) ng/L,respectively,while the control group were (180.23±15.21) ng/L,hs CRP levels of (14.15±1.35) ng/L,and IL-6 levels of (13.12±1.34) ng/L,respectively.The difference between the two groups was statistically significant (P<0.05).The average wound healing time in the experimental group was (40.5±10.6) days,while in the control group it was (65.5±4.5) days.The difference between the two groups was statistically significant (P<0.05).Conclusion After anal fistula surgery,negative pressure closed drainage treatment is adopted,which reduces the inflammatory response of the wound,speeds up the wound healing and shortens the wound healing time.

Key words: continuous negative pressure closed drainage technology, after anal fistula surgery