Abstract: Objective To explore the relationship between thrombospondin 2 (THBS2) and secreted protein acidic and rich in cysteine (SPARC) expression and oxidative stress,clinicopathological features and prognosis of gastric cancer.Methods The expression of THBS2,SPARC,xanthine oxidase (XOD) and myeloperoxidase (MPO) in 60 cases of gastric cancer and adjacent tissues collected from February 2021 to September 2022 were detected by immunohistochemical SP method.Spearman correlation test,binary Logistic regression and Kaplan-Meier method were used to analyze the impacts of THBS2 and SPARC on oxidative stress,clinicopathological features and prognosis.Results The high expression rates of THBS2,SPARC,XOD and MPO in gastric cancer tissues were 53.3%,71.7%,60.0%,70.0%,which were higher than adjacent tissues (33.3%,21.7%,38.3%,26.7%) (P<0.05).THBS2 and SPARC were positively correlated with XOD and MPO in gastric cancer (P<0.05).THBS2 expression was correlated with invasion depth,lymph node metastasis and TNM stage;SPARC expression was correlated with lymph node metastasis and TNM stage (P<0.05).Invasion depth was an independent factor affecting THBS2 expression in gastric cancer tissues (P<0.05).The median survival of high THBS2 expression group was shorter than low THBS2 expression group (P=0.029).The median survival of high SPARC expression group was longer than low SPARC expression group (P<0.001).Conclusion THBS2 and SPARC are highly expressed in gastric cancer,which are closely related to oxidative stress,clinicopathological features and prognosis.

Key words: gastric cancer, THBS2, SPARC, oxidative stress, clinicopathological features, prognosis