Abstract: Objective This study analyzes the risk factors for postoperative gastrointestinal dysfunction (POGD) in infants after intestinal surgery.Methods The perioperative clinical data of 220 infants who underwent intestinal surgery in Children’s Hospital of Nanjing Medical University from March 2019 to March 2024 were retrospectively analyzed.Based on the criteria of postoperative “fasting time more than 5d,vomiting bile fluid or bile fluid drainage from nasogastric tube,abdominal distension”,the infants were divided into POGD group(78 cases) and non-POGD group (142 cases),and the clinical data of the two groups were analyzed by one-way analysis,and the independent factors with a P<0.05 were included in the binary Logistic regression analysis to analyze the independent influencing factors affecting the recovery of gastrointestinal function after surgery.Results The time of the first defecation after surgery in the POGD group and the non-POGD group was (1.79±1.78) days and (1.44±0.71) days,respectively,and the time of parenteral nutrition was (9.73±4.64) days and (5.19±2.18) days,respectively,and the hospital stay was (13.31±5.70) days and (8.46±2.90) days,respectively.There was statistically significant difference between the two groups(P < 0.05).Multivariate regression analysis showed that a low preoperative weight for age Z(WAZ) score (P < 0.05,OR= 0.705) and a long operation time (P < 0.05,OR=2.642) were risk factors for POGD.Conclusion Preoperative nutritional status and duration of surgery are risk factors for the development of postoperative gastrointestinal dysfunction in infants.