Abstract: Objective To analyze the influencing factors of negative pressure drainage volume after transabdominal preperitoneal prosthesis（TAPP） for scrotal hernia.Methods The clinical data of 80 patients who underwent TAPP at the Department of General Surgery,Jiangsu Province Hospital of Traditional Chinese Medicine from January 2021 to December 2023 were retrospectively analyzed.According to the total drainage volume within 3 days after operation,the patients were divided into high drainage group and low drainage group,with 40 cases in each group.Univariate analysis and multivariate Logistic regression analysis were used to analyze the influencing factors of high drainage volume,and factors with significant differences were included to analyze .Plot receiver operating characteristic (ROC) curve and calculate area under curve (AUC).Results The median drainage volume was 100.00 ml (range 45.00-170.00 ml) in the first 3 days after operation,and the daily drainage volume decreased gradually.Univariate analysis showed that the diameter of hernia ring,operation time,intraoperative blood loss,albumin,and transection hernia sac(P<0.05).Logistic regression analysis showed that large hernia ring diameter,more blood loss and albumin were independent risk factors for high drainage volume(P<0.05).Hernia ring diameter >2.75 cm,blood loss >12.50 ml,albumin <31.5 g/L had high predictive value for high induced flow,and AUC was 0.916,0.908,0.904,respectively.Conclusions Large diameter of hernia ring,more intraoperative bleeding and hypoalbuminemia are independent risk factors for high drainage volume after TAPP.Negative pressure drainage tube can be placed during operation to prevent postoperative seroma.