Abstract: Objective To explore the early diagnostic value of serum heat shock protein 70 (HSP70),periosten combined with low-dose spiral CT (LDCT) for lung cancer.Methods From July 2022 to June 2024,103 lung cancer patients admitted to our hospital were regarded as the lung cancer group,and 87 patients with benign pulmonary nodules were selected as the benign group.ELISA kit was used to measure serum HSP70 and Periostin.Multivariate Logistic regression was applied to analyze the influencing factors of lung cancer.Four grid table method was applied to calculate the sensitivity,specificity,and accuracy of LDCT combined with serum HSP70 and Periostin in the diagnosis of lung cancer.Kappa test was applied to evaluate the consistency between LDCT,serum HSP70,Periostin combined with LDCT and pathological diagnosis of lung cancer.Results Compared with the benign group,the lung cancer group had greatly higher levels of serum HSP70 and Periostin (P<0.05).Compared to the benign group,the lung cancer group had higher proportions of lobulation and spiculation signs (P<0.05).Multivariate Logistic regression showed that HSP70 (OR=1.569),Periostin (OR=1.427),lobulation sign (OR=2.015),and spiculation sign (OR=1.946) were all independent risk factors for lung cancer (P<0.05).The sensitivity,specificity,and accuracy of LDCT in diagnosing lung cancer were 85.44%,88.51%,and 86.84%,respectively;the sensitivity,specificity,and accuracy of serum HSP70 and Periostin combined with LDCT in diagnosing lung cancer were 93.20%,80.46%,and 87.37%,respectively.Kappa test showed that the consistency between serum HSP70,Periostin combined with LDCT had high consistency with pathology in the diagnosis of lung cancer (Kappa value=0.743).Conclusion The serum levels of HSP70 and Periostin are higher in lung cancer patients.The combination of serum HSP70 and Periostin with LDCT has better diagnostic efficacy for lung cancer.

Key words: lung cancer, low dose spiral CT, heat shock protein 70, periostin, diagnostic value