JOURNAL OF CLINICAL SURGERY ›› 2025, Vol. 33 ›› Issue (5): 482-485.doi: 10.3969/j.issn.1005-6483.20240814

Previous Articles     Next Articles

The effect of different RLNLN dissection on the short-term efficacy,serum TREM-1,TRAP1 levels,and quality of life in patients with esophageal cancer undergoing thoracoscopic radical resection

  

  1. Department of Thoracic Surgery,The Second Affiliated Hospital of Air Force Military Medical University,Xi’an 710038,China
  • Received:2024-05-28 Accepted:2024-05-28 Online:2025-05-20 Published:2025-05-20

PDF (PC)

15

PDF (Mobile)

0

Abstract: Objective  To investigate the impact of different lymph node dissection (RLNLN) around the recurrent laryngeal nerve (RLN) on the clinical efficacy of esophagectomy (EC) with thoracoscopic radical surgery.Methods Ninety-eight EC patients were selected from 2022-01 to 2022-10 in our hospital and divided into the control group and the study group,each with 49 cases,using simple randomization method.Both groups underwent EC thoracoscopic radical surgery,with conventional RLNLN clearance in the control group and modified RLNLN clearance in the study group.The operation and postoperative recovery of the two groups were compared,as well as myeloid triggered receptor-1 (TREM-1),tumor necrosis factor receptor-associated protein-1 (TRAP1),and complications before and after the operation,and the recurrence rate and survival rate of the two groups were counted at 1 year after the operation.Results The RLNLN dissection time in the study group was (11.93±3.57) minutes,which was shorter than that in the control group (17.15±4.28) minutes.The number of RLNLN dissections on both sides was (7.19±1.24),which was higher than that in the control group (5.56±1.10),and the differences were statistically significant (P<0.05).Three and seven days after surgery,the CD3+,CD4+/CD8+ of the study group were higher than those of the control group,while CRP,PCT,TREM-1,and TRAP1 were lower than those of the control group,and the differences were statistically significant (P<0.05).The postoperative complication and recurrence rates in the study group were 4.08% (2/49) and 10.87% (5/46),respectively,which were lower than the control group[18.37%(9/44),29.55% (13/44)].Conclusion Thoracoscopic radical resection of esophageal cancer with modified RLNLN dissection can can enhance the effect of lymph node clearance,down-regulate the expression of TREM-1 and TRAP1,reduce the inflammatory response of the body,regulate the immune function,reduce the risk of complications and recurrence,and improve the quality of life.

Key words: esophageal cancer, thoracoscopic radical surgery, paralaryngeal lymph node of the recurrent laryngeal nerve, complication, recurrence

[1] YANG Sanhu, LI Yan, HUANG Lijun, YAN Zhenke, LIU Xu, LI Wanshan, JI Xiang . A random forest prediction study on the 3-year recurrence-free survival of early and middle stage esophageal cancer after total endoscopic resection [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(5): 486-492.
[2] LU Hai, FU Qin, ZHU Yunhe, ZHANG Xianzheng. Impacts of midazolam on the proliferation,migration,and invasion of esophageal cancer cells by regulating the CCL2-CCR2 signaling pathway [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(5): 493-497.
[3] LIU Tianpeng, LU Shixin, MENG Xianzhi.. Analysis of risk factors for common bile duct stones secondary to asymptomatic cholecystolithiasis [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(5): 507-510.
[4] TAO Jiazheng, FENG Shiyou, CHEN Gang. Establishment and validation of a risk model for postoperative recurrence of liver and bile duct stones [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(4): 416-419.
[5] WANG Mingshu. Selection and effect analysis of emergency surgical approach for inguinal hernia in primary hospital [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(4): 429-432.
[6] JIA Yong,SHEN Junlong,FAN Chao,WANG Junqi. MiR-362-3p regulates the proliferation,migration and invasion of esophageal cancer cells by targeting dual specificity phosphatase 10 [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(3): 256-260.
[7] WANG Yifeng，HUA Rong，HE Yi. Influencing factors of postoperative complications of elderly patients with esophageal cancer with Clavien-Dindo grade ≥Ⅲ and construction of nomogram prediction model [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(3): 261-266.
[8] ZHU Yuan,YU Jin,SUN Huapeng,LI Xiaogang,LIAO Xiaofeng. Observation of therapeutic effects of Chen's pancreatojejunostomy in laparoscopic pancreaticoduodenectomy [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(3): 289-293.
[9] YANG Lin, HAN Yugang, LIANG Xiang. Relationship between the expression of microRNA-433-3p and βV-tubulin in bladder cancer and pathological characteristics and their predictive value for postoperative recurrence [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(2): 175-178.
[10] TAO Qi, NIE Long, WANG Yihui, WANG Weimin, ZHENG Wu. Comparison of electrochemical therapy by Cupric ion and selective suprahemorrhoid mucosal resection and stapling surgery for the treatment of grade Ⅲ-Ⅳ hemorrhoids [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(2): 183-186.
[11] YUAN Hao, TENG Jingyan, ZHANG Qiang. Research progress of immunotherapy in neoadjuvant therapy of esophageal cancer [J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(2): 210-212.
[12] ZHANG Nianlong,LI Xuyang,YANG Yunlong,PENG Hao,ZHOU Jianlin. Research progress on the influence of operative time on patients after total knee arthroplasty [J]. JOURNAL OF CLINICAL SURGERY, 2024, 32(9): 998-1001.
[13] KANG Shuhong, LYU Feng, NI Yunfeng, YUN Junru. Clinical value of miR-27a and miR-1299 in predicting  prognosis of patients with esophageal cancer [J]. JOURNAL OF CLINICAL SURGERY, 2024, 32(8): 803-806.
[14] WANG Jichao, XUE Junying, ZHANG Jianhua, YANG Jin, WANG Linpei. The effect of improved total cavity endoscopy on lung function,postoperative feeding and complications in patients with chronic lung disease of esophageal cancer [J]. JOURNAL OF CLINICAL SURGERY, 2024, 32(8): 807-810.
[15] LI Jin, ZHU Fuying, XU Ya, LAN Yuntong. Predictive efficacy of miR-27b-3p combined with miR-215 in the recurrence of early gastric cancer after endoscopic submucosal dissection [J]. JOURNAL OF CLINICAL SURGERY, 2024, 32(8): 830-834.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(10): 735 .
[2] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(10): 789 .
[3] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(11): 812 .
[4] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(11): 835 .
[5] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(11): 867 .
[6] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(12): 919 .
[7] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(4): 247 - 247 .
[8] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(5): 356 -0 .
[9] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(5): 375 -0 .
[10] . [J]. JOURNAL OF CLINICAL SURGERY, 2016, 24(5): 327 -0 .
Copyright © JOURNAL OF CLINICAL SURGERY, All Rights Reserved.
Tel: 027-87893476　E-mail: whlcwk@126.com
Powered by Beijing Magtech Co. Ltd