Abstract: Objective To analyze the expression,change and clinical significance of insulin like growth factor 2 (IGF2) in Type A Aortic Dissection (TAAD).Methods Tissue samples of 9 TAAD patients from January 2015 to December 2019, and aortic tissue samples of 5 patients pruned from heart transplant donors were obtained. Hematoxylin - eosin (HE) staining and elastic fiber (EVG) staining were used to evaluate the structural changes of the aorta in the two groups. The protein expression of IGF2 in aortic wall tissues of the two groups was detected by Western Blot. Immunohistochemical staining (IHC) was used to detect the subcellular distribution and expression of IGF2 in the two groups of samples.Results Hematoxylin-eosin staining (HE) and elastic fiber Verhoeff’s Van Gieson staining (EVG) showed that the cells in the aortic wall tissue of aortic dissection became smaller and disordered,and the elastic fibers became thinner,fractured and disordered.The expression level of IGF2 in aortic wall tissue of TAAD was decreased,and the difference between the two groups was statistically significant (P<0.05).IHC showed that IGF2 was expressed in nucleus,and the expression level in aortic dissection tissues was significantly lower than that in normal tissues,with statistical significance (P<0.05).Conclusion The decreased expression level of IGF2 in aortic wall tissues of TAAD patients may be related to the occurrence of aortic dissection,and IGF2 is expected to be a new target for the prevention and treatment of aortic dissection.

Key words: aortic dissection; insulin like growth factor 2; apoptosis; proliferation