Abstract: Objective  To verify the superiority and safety of natural orifice specimen extraction surgery(NOSES)compared with traditional laparoscopic surgery in patients with colorectal cancer. Methods The clinical data of 128 patients underwent colorectal cancer surgery in our department from January 2018 to October 2021 were retrospectively analyzed,including 60 NOSES and 68 traditional laparoscopic surgery,and the differences of intraoperative and postoperative indicators were compared between the two groups. Results The NOSES group was superior to the traditional laparoscopic group in incision length [(3.93±0.10)cm vs(10.77±1.23)cm],pain score [(3.52±1.13)points vs(4.12±1.11)points],first activity time [(19.13±6.81)h vs(25.03±9.38)h],exhaust time [(52.23±14.05)h vs(61.59±16.87)h],nutrition score [(3.92±0.96)points vs(4.41±1.04)points],length of hospital stay [(11.22±2.22)d vs(12.59±2.36)d](P<0.05).There was no difference in operation time [(142.41±20.28)min vs(138.63±17.92)min],blood loss [(62.58±35.68)ml vs(66.03±51.34)ml],number of lymph nodes dissected [(11.15±2.62)vs(10.59±2.54)] and complications(20.00% vs 22.06%)between the two groups(P>0.05). Conclusion NOSES was more superior in aesthetics,pain and rehabilitation when ensuring the safety of surgery.

Key words: natural orifice specimen extraction surgery, laparoscopic surgery, colorectal cancer