Abstract: Objective To analyze the correlation between CT signs and the expression of Ki-67,golgi phosphoprotein 3(GOLPH3) in patients with lung cancer.Methods 120 patients with lung cancer admitted tofrom January 2019 to April 2021 were selected.They were examined by CT.The CT signs(tumor diameter,location,burr sign,deep lobulation sign and necrotic cavity) were collected.The expression of Ki-67,GOLPH3 in lung cancer tissue was detected by immunohistochemistry,and the correlation between CT signs and the expression of Ki-67,GOLPH3 was analyzed.Results Among the 120 cases of lung cancer,76 cases(63.33%) had lesion diameter > 3cm,61 cases(50.83%) had peripheral lung cancer,84 cases(70.00%) had no necrotic cavity,71 cases(59.17%) had no burr sign,79 cases(65.83%) had deep lobulation sign.The positive rate of Ki-67 was 88.33%(106/120) and the positive rate of GOLPH3 was 79.17%(95/120).The expression of Ki-67,GOLPH3 in lung cancer tissues was positively correlated(r=0.381,0.271,P=0.000,0.018).The expression of Ki-67 and GOLPH3 in lung cancer was correlated with cavity,burr and deep lobulation.The expression of Ki-67 and GOLPH3 were significantly different among the four pathological types(P＜0.05).The expression of Ki-67 and GOLPH3 in the pathological grade Ⅲ~Ⅳ were significantly higher than that in gradeⅠ~Ⅱ(P<0.05).Conclusion There is a correlation between CT image features and Ki-67,GOLPH3 positive expression in lung cancer,which can provide reliable basis for evaluating tumor proliferation and predicting prognosis.

Key words: lung cancer, Ki-67, GOLPH3, CT signs