Abstract: Objective Based on the Wntβ-catenin signaling pathway,the effect of macrophages on osteolysis after artificial hip replacement was investigated.Methods 60 patients without osteolysis and 55 patients with osteolysis after secondary femoral head necrosis in the later stage of femoral neck fracture were collected as the control group and the study group respectively.The concentration of IL-6,TNF-α,β-CTX,CD206,CD68,β-catenin protein were detected.Correlation analysis of continuous variables were tested by Pearson.Results The levels of IL-6,TNF-α and β-CTX,CD206 protein expression and the CD206/CD68 ratio of the study group were significantly higher than those of the control group(P<0.05),while the CD68 and β-catenin protein expressions were significantly lower than the control group(P<0.05).β-catenin was negatively correlated with CD206,positively correlated with CD68,negatively correlated with CD206/CD68 ratio(P<0.05).IL-6,TNF-α,β-CTX were positively correlated with CD206 and CD206/CD68,negatively correlated with CD68(P<0.05).Conclusion In THA patients,inhibition of the β-catenin pathway promotes the polarization of macrophages to M1 type,causing an inflammatory response,leading to osteolysis.

Key words: total hip replacement, osteolysis, macrophages, Wnt/β-catenin pathway