Abstract: [Abstract] ObjectiveTo explore the learning curve assessment for percutaneous trans-jugular vein closure of atrial septal defect with curve-controllable sheath catheter.MethodsThe present analysis included 40 atrial septal defect patients who were consecutively undergone percutaneous trans-jugular vein closure with curve-controllable sheath catheter from a single-center between January 2015 and June 2018.The procedure time,puncture time，intracardiac operation time and intraoperative blood loss were recorded．The learning curve of percutaneous trans-jugular vein closure of atrial septal defect with curve-controllable sheath catheter was analyzed with cumulative summation(CUSUM)．Results40 cases were underwent interventional therapy successfully.The average time of procedure,puncture time，intracardiac operation were(31.2±8.7)min,(17.1±4.4)min and (14.1±5.3)min,respectively;and the average amount of intraoperative blood loss was(7.6±1.8)ml.The fitting equation was Σi(CUSUM)= 0.001X3-0.123X2+3.264X-2.420,and the R² value was 0.99.The curve slope turned into negative at the 18th case.18 was the minimum number of surgeries that need to be accumulated to cross the learning curve.Conclusion With the increasing of operator’s experience,the safety of percutaneous trans-jugular vein closure of atrial septal defect with curve-controllable sheath catheter was increased.It is suggested from our data that the surgeons need finish about 18 cages to skill this surgery method．

Key words: jugular vein, curvecontrollable sheath catheter, atrial septal defect, closure, learning curve