Abstract: Objective To analyze the characteristics of breast microcalcification(MC) in patients with T1～2 stage human epidermal growth factor receptor 2(HER2) positive and non-positive invasive breast cancer(IBC). Methods Retrospectively analyzed the clinicopathological data of 254 patients with T1～2 stage IBC.To analyze the occurrence and characteristics of MC in HER2 positive and non-positive patients. Results In this study,the incidence of MC was 53.54%(136/254),The incidence of MC in the HER2 positive group was higher than that in the non-positive group(79.37%vs 45.03%， P<0.05).In HER2 positive group,MC was mainly branching samples of thin lines distributed along ducts,while in non-positive group,it was more common to have needle tip like cluster distribution.There were significant differences in MC morphology and distribution between the two groups(P＜0.05).In HER2 positive patients,the incidence of MC in patients who was older than 50 years was higher than that in patients who was 50 years and younger(P＜0.05). Conclusion The incidence of MC was higher in HER2-positive IBC patients,and the morphology and distribution of MC had certain guiding significance in predicting the expression status of HER2.

Key words: invasive breast carcinoma, human epidermal growth factor receptor-2, microcalcification