Abstract: Objective To evaluate the effect of children laparoscopic surgery on regional cerebral oxygenation.Methods Forty ASAⅠ～Ⅱ children ，aged 5～10 yr，scheduled for elective appendectomy，were divided into 2 groups by the surgical indication（n=20 each）：laparoscopic surgery group（group L）and open appendectomy group（group O）.General anesthesia with endotracheal intubation which was induced with sufentanil，propfol and rocuronium，and maintained with infusion of remifentanil and propfol in both groups，and 80 percents oxygen concentration was given in mechanical ventilation in both groups.The time of operation and anesthesia，the endtidal carbon dioxide pressure（P_ETCO₂），hemodynamic variables ，such as heart rate（HR），mean arterial pressure（MAP），oxygen saturation（SpO₂），left and right regional cerebral oxygen saturation（RrScO₂ and LrScO₂，）were recorded after anesthesia induction and before start of surgery（T₀），15 min after start of surgery（T₁），30 min after start of surgery（T₂），45 min after start of surgery（T₃），60 min after start of surgery（T₄）and end of the surgery（T₅）.Results The P_ETCO₂ was higher in group L ，compared with group O at T₁、T₂、T₃，there were progressive decreases in both  LrScO₂（L：77.2±5.5，O：79.2±5.5）and RrScO₂ （L：80.1±5.1，O：81.6±3.2）at T₁，compared with T₀ in both two groups，but both were within the normal range.Which were not statistically significant at T₀，T₁，T₂，T₃，T₄，T₅（P>0.05）.Conclusion The laparoscopic surgery may not affect cerebral oxygenation in pediatric patients.

Key words: 小儿麻醉, 腹腔镜手术, 局部脑氧饱和度