低剂量螺旋CT联合血清热休克蛋白70、骨膜蛋白在肺癌早期诊断中的应用价值

doi:10.3969/j.issn.1005-6483.20241583

临床外科杂志 ›› 2025, Vol. 33 ›› Issue (10): 1069-1072.doi: 10.3969/j.issn.1005-6483.20241583

低剂量螺旋CT联合血清热休克蛋白70、骨膜蛋白在肺癌早期诊断中的应用价值

王少华汪春荣黄晓燕刘勇彬刘志新

518052 广东深圳，深圳市南山区人民医院放射科(王少华、汪春荣、刘勇彬)，胸外科(刘志新)；广州医科大学附属第一医院放射科(黄晓燕)

收稿日期:2024-09-29 出版日期:2025-11-11 发布日期:2025-11-11
通讯作者: 刘勇彬，Email:xtivh21@163.com
基金资助:
广东省医学科学技术研究基金项目(A2023238)

The application value of serum heat shock protein 70,Periostin combined with low-dose spiral CT in early diagnosis of lung cancer

WANG Shaohua^*,WANG Chunrong,HUANG Xiaoyan,LIU Yongbin,LIU Zhixin

^*Department of Radiology,Nanshan District People's Hospital,Shenzhen 518052,China

Received:2024-09-29 Online:2025-11-11 Published:2025-11-11

摘要/Abstract

摘要： 目的探讨低剂量螺旋CT(LDCT)联合血清热休克蛋白70(HSP70)、骨膜蛋白(Periostin)对肺癌的早期诊断价值。方法选取2022年7月~2024年6月收诊的103例肺癌病人作为肺癌组，同期87例肺部良性结节病人为良性组。ELISA试剂盒检测血清HSP70和Periostin。采用多因素Logistic回归分析肺癌诊断的影响因素；采用四格表法计算LDCT及血清HSP70、Periostin联合LDCT诊断肺癌敏感度、特异度、准确度；Kappa检验评估LDCT及血清HSP70、Periostin联合LDCT与病理学诊断肺癌的一致性。结果与良性组比较，肺癌组血清HSP70、Periostin水平均升高，差异有统计学意义(P＜0.05)。与良性组比较，肺癌组出现分叶征及毛刺征的占比较多，差异有统计学意义(P＜0.05)。多因素Logistic回归显示，HSP70(OR=1.569)、Periostin(OR=1.427)、分叶征(OR=2.015)和毛刺征(OR=1.946)均为肺癌的独立危险因素(P＜0.05)。LDCT诊断肺癌的敏感度为85.44%，特异度为88.51%，准确度为86.84%；血清HSP70、Periostin联合LDCT诊断肺癌的敏感度为93.20%，特异度为80.46%，准确度为87.37%。Kappa检验显示，LDCT联合血清HSP70、Periostin与病理学诊断肺癌的一致性较高(Kappa=0.743)。结论肺癌病人血清HSP70、Periostin水平较高，LDCT联合血清HSP70、Periostin对肺癌的诊断效能较佳。

关键词: 肺癌, 低剂量螺旋CT, 热休克蛋白70, 骨膜蛋白, 诊断价值

Abstract: Objective To explore the early diagnostic value of serum heat shock protein 70 (HSP70),periosten combined with low-dose spiral CT (LDCT) for lung cancer.Methods From July 2022 to June 2024,103 lung cancer patients admitted to our hospital were regarded as the lung cancer group,and 87 patients with benign pulmonary nodules were selected as the benign group.ELISA kit was used to measure serum HSP70 and Periostin.Multivariate Logistic regression was applied to analyze the influencing factors of lung cancer.Four grid table method was applied to calculate the sensitivity,specificity,and accuracy of LDCT combined with serum HSP70 and Periostin in the diagnosis of lung cancer.Kappa test was applied to evaluate the consistency between LDCT,serum HSP70,Periostin combined with LDCT and pathological diagnosis of lung cancer.Results Compared with the benign group,the lung cancer group had greatly higher levels of serum HSP70 and Periostin (P<0.05).Compared to the benign group,the lung cancer group had higher proportions of lobulation and spiculation signs (P<0.05).Multivariate Logistic regression showed that HSP70 (OR=1.569),Periostin (OR=1.427),lobulation sign (OR=2.015),and spiculation sign (OR=1.946) were all independent risk factors for lung cancer (P<0.05).The sensitivity,specificity,and accuracy of LDCT in diagnosing lung cancer were 85.44%,88.51%,and 86.84%,respectively;the sensitivity,specificity,and accuracy of serum HSP70 and Periostin combined with LDCT in diagnosing lung cancer were 93.20%,80.46%,and 87.37%,respectively.Kappa test showed that the consistency between serum HSP70,Periostin combined with LDCT had high consistency with pathology in the diagnosis of lung cancer (Kappa value=0.743).Conclusion The serum levels of HSP70 and Periostin are higher in lung cancer patients.The combination of serum HSP70 and Periostin with LDCT has better diagnostic efficacy for lung cancer.

Key words: lung cancer, low dose spiral CT, heat shock protein 70, periostin, diagnostic value

王少华汪春荣黄晓燕刘勇彬刘志新. 低剂量螺旋CT联合血清热休克蛋白70、骨膜蛋白在肺癌早期诊断中的应用价值[J]. 临床外科杂志, 2025, 33(10): 1069-1072.

WANG Shaohua, WANG Chunrong, HUANG Xiaoyan, LIU Yongbin, LIU Zhixin. The application value of serum heat shock protein 70,Periostin combined with low-dose spiral CT in early diagnosis of lung cancer[J]. JOURNAL OF CLINICAL SURGERY, 2025, 33(10): 1069-1072.

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低剂量螺旋CT联合血清热休克蛋白70、骨膜蛋白在肺癌早期诊断中的应用价值

The application value of serum heat shock protein 70,Periostin combined with low-dose spiral CT in early diagnosis of lung cancer

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