关键词: 碱性亮氨酸拉链ATF样转录因子, 肾透明细胞癌, 预后, 免疫浸润, 生物标志物

Abstract: Objective To explore the roles of the basic leucine zipper ATF-like transcription factor (BATF) in the progression of kidney renal clear cell carcinoma (KIRC). Methods The expression levels of BATF in KIRC,and the roles of BATF in prognosis and immunity were analyzed using the UALCAN,TISIDB, Kaplan-Meier plotter,OncoLnc and Sangerbox databases. Results The expression level of BATF in KIRC tissues was significantly increased and correlated with the poor Overall survival.BATF overexpression was significantly associated with cancer stage,histological subtype,and lymph node metastasis in patients with KIRC.In addition,the methylation level of BATF in KIRC tissues was negatively correlated with tumor stage,tumor grade,and lymph node metastasis.BATF overexpression was positively correlated with the immune B cells,CD8+T cells,CD4+T cells,macrophages,and dendritic cells. Conclusion BATF was highly expressed in KIRC.BATF overexpression was associated with the poor prognosis in patients with KIRC,and was associated with KIRC immune infiltration cells,indicating that BATF was expected to be a biomarker and immune-related marker molecule for the poor prognosis of KIRC.

Key words: basic leucine zipper ATF-like transcription factor, kidney renal clear cell carcinoma, prognosis, Immune infiltration, biomarker