关键词: 前列腺癌, miR-485-5p, 病理, 预后

Abstract: Objective To explore the relationship between circulating miR-485-5p levels and pathological parameters of prostate cancer patients and its prognostic value. Methods A prospective study was conducted on 103 patients with prostate cancer admitted to the hospital from October 2016 to November 2018.All patients underwent radical surgery for prostate cancer and were followed up for 3 years.The relative expression of miR-485-5p was detected in all patients before operation.The relative expression of miR-485-5p in serum of prostate cancer patients with different pathological parameters was analyzed.Factors affecting the recurrence and metastasis of prostate cancer patients were analyzed.The value of serum miR-485-5p relative expression in predicting postoperative recurrence and metastasis of prostate cancer patients was analyzed.The relationship between the relative expression of miR-485-5p and the prognosis of prostate cancer patients was analyzed. Results The relative expression of miR-485-5p in patients with Gleason score>7,microvascular invasion,lymph node metastasis,and stage Ⅲ was lower than Gleason score ≤7 points,no microvascular invasion,no lymph node metastasis,and stage Ⅰ-Ⅱ(P<0.05).As of the end of follow-up,10 patients were lost to follow-up,and 35 of the remaining 93 prostate cancer patients had recurrence and metastasis.Cox regression analysis showed Gleason score,stage,relative expression of miR-485-5p was independent factor affecting postoperative recurrence and metastasis of prostate cancer patients(P<0.05).ROC curve results showed that the sensitivity of serum miR-485-5p level to predict postoperative recurrence and metastasis of prostate cancer patients was 74.29%,and the specificity was 75.86%,AUC was 0.795.The best cut-off point(1.02) for predicting postoperative recurrence and metastasis of prostate cancer patients with the relative expression of preoperative serum miR-485-5p is the dividing line.41 patients with low miR-485-5p expression survived 21 patients,and 52 patients with high miR-485-5p expression survived 37 patients;patients with high miR-485-5p expression had better disease-free survival curves than miR-485 For patients with low expression of -5p(P<0.05). Conclusion The expression of miR-485-5p is related to the pathological parameters and prognosis of prostate cancer patients.Patients with low miR-485-5p expression have a high risk of poor prognosis.

Key words: prostate cancer, miR-485-5p, pathology, prognosis