临床外科杂志 ›› 2022, Vol. 30 ›› Issue (9): 839-843.doi: 10.3969/j.issn.1005-6483.2022.09.011

• 论著 • 上一篇    下一篇

胃癌组织中维甲酸相关孤儿受体α、微管相关蛋白轻链3的表达与病人远期预后的关系

  

  1. 116021 大连大学附属新华医院肛肠科
  • 收稿日期:2021-10-12 接受日期:2021-10-12 出版日期:2022-09-20 发布日期:2022-10-14
  • 通讯作者: 倪志海,Email:28814939@qq.com

Relationship between the expression of retinoid acid receptor related orphan receptorα and microtubuleassociated protein light chain 3 in gastric cancer and long-term prognosi

  1. Department of AnoRectal Surgery,Dalian University affiliated Xinhua Hospital Anorectal,Liaoning,Dalian 116021,China
  • Received:2021-10-12 Accepted:2021-10-12 Online:2022-09-20 Published:2022-10-14

摘要: 目的 分析胃癌组织中维甲酸相关孤儿受体α(RORα)、微管相关蛋白轻链3(MAPLC3)的表达与病人远期预后的关系。方法 2018年1月~2018年6月我院收治的胃癌病人82例,均经病理检查确诊,采用免疫组织化学染色法检测胃癌组织及癌旁组织中RORα、MAPLC3表达。随访3年病人生存情况,将病人分为死亡组(32例)和存活组(50例),比较两组胃癌组织中RORα、MAPLC3的表达及其与远期预后的关系。结果 癌组织中RORα阳性表达率为42.68%,MAPLC3阳性表达率为43.90%,癌旁组织分别为84.15%、91.46%,两种组织比较差异有统计学意义(P<0.05);胃癌组织中RORα、MAPLC3表达与病人性别、年龄、肿瘤直径、癌细胞类型、病理分级无关,差异无统计学意义(P>0.05);RORα表达与T分期、淋巴结转移有关(P<0.05),MAPLC3表达与T分期、分化程度、淋巴结转移有关(P<0.05)。胃癌病人远期预后单因素分析结果显示,T分期、分化程度、淋巴结转移、RORα表达、MAPLC3表达等因素与胃癌病人远期预后密切相关(P<0.05); 胃癌病人远期预后多因素COX回归分析,显示T分期(OR=1.779,95%CI:1.109~5.656)、分化程度(OR=1.621,95%CI:1.029~2.554)、淋巴结转移(OR=1.876,1.020~3.451)、RORα(OR=2.815,95%CI:1.401~5.656)、MAPLC3(OR=3.080,95%CI:1.305~7.268)是胃癌病人远期预后的独立危险因素(P<0.05);胃癌组织中RORα阳性表达评估胃癌病人预后生存的曲线下面积为0.67(95%CI:1.024~3.216),敏感性为72.34%,特异度为64.58%;胃癌组织中MAPLC3阳性表达评估胃癌病人预后生存的曲线下面积为0.65(95%CI:1.023~2.547),敏感性为74.52%,特异度为65.13%。结论 胃癌组织中RORα、MAPLC3呈较低表达,RORα、MAPLC3低表达是胃癌病人远期预后的独立危险因素。

关键词: 胃癌, 维甲酸相关孤儿受体α, 微管相关蛋白轻链3, 远期预后, 相关性

Abstract: Objective To investigate the relationship between the expression of RORα and MAPLC3 in gastric cancer and long-term prognosis. Methods A total of 82 patients admitted to our hospital from January 2018 to June 2018 who were diagnosed with gastric cancer by pathological examination were selected as the research subjects.The expression of Retinoic acid-associated orphan receptor α(RORα) and microtubule associated protein light chain 3(MAPLC3) in gastric cancer tissues and adjacent tissues was detected by immunohistochemical staining,and their correlation with pathological factors was analyzed.Patients were divided into the death group(n=32) and the survival group(n=50),and the long-term prognosis of RORα and MAPLC3 expression in gastric cancer tissues of the two groups were analyzed and compared. Results The positive expression rates of RORα(42.68%) and MAPLC3(43.90%) in cancer tissues were significantly lower than those in adjacent tissues(84.15% and 91.46%),with statistical significance(P<0.05).The positive expressions of RORα and MAPLC3 in gastric cancer tissues had no significant differences with gender,age,tumor size,cancer cell type and pathological grade(P>0.05).The positive expression of RORα was related to T stage and lymphatic metastasis(P<0.05),and the positive expression of MAPLC3 was related to T stage,differentiation degree and lymphatic metastasis(P<0.05).Univariate analysis of long-term prognosis of gastric cancer patients showed that T stage,degree of differentiation,lymphatic metastasis,RORα expression,MAPLC3 expression and other factors were closely correlated with long-term prognosis of gastric cancer patients(P<0.05).Multivariate COX regression analysis showed that T stage(OR=1.779,95%CI:1.109~5.656) and differentiation degree(OR=1.621,95%CI:1.029~2.554),lymphatic metastasis(OR=1.876,1.020~3.451),RORα(OR=2.815,95%CI:1.401~5.656),MAPLC3(OR=3.080,95%CI:1.305~7.268) were independent risk factors for long-term prognosis of gastric cancer patients(P<0.05).The area under the curve for evaluating the prognosis and survival of gastric cancer patients was 0.67(95%CI:1.024~3.216),with a sensitivity of 72.34% and specificity of 64.58%.The area under the curve of MAPLC3 positive expression in gastric cancer tissues was 0.65(95%CI:1.023~2.547),with a sensitivity of 74.52% and specificity of 65.13%.Conclusion The expressions of RORα and MAPLC3 were lower in gastric cancer tissues.The positive expressions of RORα and MAPLC3 are independent risk factors for long-term prognosis of gastric cancer patients.

Key words: gastric cancer, retinoic acidrelated orphan receptor α, microtubuleassociated protein light chain 3, longterm prognosis, correlation

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