临床外科杂志 ›› 2022, Vol. 30 ›› Issue (4): 353-356.doi: 10.3969/j.issn.1005-6483.2022.04.015

• 论著 • 上一篇    下一篇

PTEN磷酸化在胃癌组织中的表达与临床病理特征及预后的相关性

  

  1. 114000 辽宁省鞍山市中心医院普外科
  • 收稿日期:2021-06-01 接受日期:2021-06-01 出版日期:2022-04-20 发布日期:2022-04-20
  • 通讯作者: 成亮,Email：duzhi8899368@163.com

The expression of PTEN phosphorylation in gastric cancer and its correlation with clinicopathological characteristics and prognosis

  1. Department of General Surgery,Anshan Central Hospital,Liaoning,Anshan 114000, China
  • Received:2021-06-01 Accepted:2021-06-01 Online:2022-04-20 Published:2022-04-20

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摘要： 目的 研究PTEN磷酸化(p-PTEN)在胃癌组织中的表达水平，探讨其与胃癌病人临床病理特征及预后的相关性。 方法 2015年1月～2016年1月我院行胃癌根治术并经病理证实的胃癌病人85例，收集其胃癌组织标本和癌旁组织；采用免疫组化分析胃癌组织及癌旁组织中p-PTEN的表达情况；根据胃癌组织中p-PTEN的表达情况，将胃癌病人分为p-PTEN低表达组和p-PTEN高表达组；比较两组胃癌病人临床病理资料及预后的差异，分析影响病人生存期的危险因素。 结果 胃癌组织中p-PTEN低表达51例，高表达34例；癌旁组织中p-PTEN低表达69例，高表达16例。胃癌组织中的p-PTEN表达水平高于癌旁组织，两组比较差异有统计学意义( P < 0.05 )；p-PTEN的高表达与胃癌病人的分化程度、浸润深度、TNM分期及转移率存在相关性( P <0.05)；Kaplan-Meier分析结果表明，p-PTEN 高表达病人的总生存期(OS)较p-PTEN低表达病人缩短(χ2=14.296， P ＜0.001)；多因素Cox比例风险回归模型分析显示，CEA、CA19-9、TNM分期、淋巴结转移及pPTEN表达水平是影响胃癌病人OS的独立风险因素( P < 0.05)。 结论 胃癌病人p-PTEN水平升高，其p-PTEN水平与胃癌病人的临床病理特征密切相关，与OS呈负相关。

关键词: 胃癌, PTEN磷酸化, 免疫组化, 总生存期

Abstract: Objective To study the expression level of PTEN phosphorylation(p-PTEN) in gastric cancer tissues,and to explore its correlation with the clinicopathological characteristics and prognosis of gastric cancer patients. Methods Collect 85 cases of gastric cancer patients who underwent radical gastric cancer surgery in our hospital from January 2015 to January2016 and were confirmed by pathology,and collected their gastric cancer tissue specimens and adjacent tissues;Immunohistochemistry was used to analyze the expression of p-PTEN in gastric cancer tissues and adjacent tissues;at the same time,according to the expression of p-PTEN in gastric cancer tissues,gastric cancer patients were divided into p-PTEN low expression group and high expression group;Compare the differences in clinicopathological data and prognosis between the two groups of gastric cancer patients,and analyze the risk factors that affect the survival of gastric cancer patients. Results In gastric cancer tissues,51cases had low expression and 34 cases had high expression of p-PTEN;in the adjacent tissue,69 cases had low expression and 16 cases had high expression.The expression level of p-PTEN in gastric cancer tissue was significantly higher than that in adjacent tissue,and the difference between the two groups was statistically significant( P <0.05).The high expression of p-PTEN was correlated with the degree of differentiation,depth of invasion,TNM stage and metastasis rate of gastric cancer patients( P <0.05).p-PTEN low expression patients were significantly shortened(χ2=14.296, P <0.001).Multivariate Cox proportional hazards regression model analysis showed that CEA,CA19-9,TNM stage,lymph node metastasis and p-PTEN expression were independent risk factors for OS in gastric cancer patients( P <0.05). Conclusion The level of p-PTEN in patients with gastric cancer is significantly increased.The level of p-PTEN is closely related to the clinicopathological characteristics of patients with gastric cancer,and is negatively related to overall survival.

Key words: gastric cancer, PTEN phosphorylation, immunohistochemistry, overall survival

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