临床外科杂志 ›› 2019, Vol. 27 ›› Issue (12): 1049-1052.doi: 10.3969/j.issn.1005-6483.2019.12.012

• • 上一篇    下一篇

直肠癌前切除术后生活质量及前切除综合征相关因素分析

  

  1. 215600 江苏省苏州市张家港市第一人民医院肛肠科(徐玲);南京中医药大学第三附属医院全国中医肛肠医疗中心(丁曙晴、丁义江)
  • 出版日期:2019-12-20 发布日期:2019-12-20
  • 通讯作者: 丁义江,Email:njgczx@gmail.com

Quality of life after anterior resection of rectal cancer and analysis of related factors of anterior resection syndrome

  1. Department of Anorectal Surgery,the First People's Hospital of Zhangjiagang,Jiangsu,Suzhou 215600,China
  • Online:2019-12-20 Published:2019-12-20

摘要: 目的 调查直肠癌前切除术后病人排便状况及生活质量,分析前切除综合征(ARS)的相关因素。方法 2010年5月~2016年5月因直肠癌行直肠前切除术后病人100例,病人填写低位ARS评分表(LARS评分表)、EORTC QLQ-C30(V3.0)生活质量量表,共获得完整资料85例。按照LARS评分表,将病人分为重度ARS、无/轻度ARS两组,比较两组病人的生活质量,综合分析相关因素。结果 ARS病人45例(52.9%),包括重度30例(35.3%),轻度15例(17.6%);ARS各症状的发生比率依次为里急后重(69.4%)>排便急迫(57.7%)>气体失禁(52.9%)>便频(42.4%)>稀便失禁(38.8%)>便秘(11.7%)。比较重度ARS、无/轻度ARS病人的EORTC QLQ-C30得分:在总体健康水平、所有功能维度(躯体功能、角色功能、情绪功能、认知功能、社会功能)、疲倦、腹泻方面的差异有统计学意义(P<0.05),重度ARS病人生活质量明显更差。年龄、肿瘤下缘距肛缘的距离、放疗是直肠癌前切除术后发生重度ARS的危险因素(P<0.05),但均不是独立危险因素(P>0.05)。结论 直肠癌前切除术后病人的生活质量与ARS的发生密切相关,重度ARS病人生活质量较差。高龄、肿瘤位置较低以及曾接受放疗的病人更容易发生重度ARS。

关键词: 直肠癌, 前切除综合征, 生活质量, 相关因素

Abstract: Objective To investigate the defecation status and quality of life of patients after anterior resection of rectal cancer,and to analyze the related factors of anterior resection syndrome.Methods From May 2010 to May 2016,a total of 100 cases of patients with rectal cancer who underwent anterior rectal resection in Nanjing Hospital of TCM were followed up.Patients were asked to fill in LARS score form and EORTC qlq-c30(V3.0)quality of life scale.A total of 85 cases of complete data were obtained.According to LARS score table,patients were divided into two groups,major anterior resection syndrome and no/minor anterior resection syndrome,to compare the quality of life of two groups and analyze relevant factors.Results A total of 45/85 patients(52.9%)with anterior resection syndrome were diagnosed.These included 30/85 patients with major anterior resection syndrome(35.3%)and 15/85 patients with minor anterior resection syndrome(17.6%).The incidence rate of each symptom of preoperative resection syndrome was tenesmus(69.4%)> urgency of defecation(57.7%)> incontinence of gas(52.9%)> frequency of defecation(42.4%)> incontinence of liquid(38.8%)>  constipation(11.7%).Compare major anterior resection syndrome,no/minor anterior resection syndrome in patients with EORTC QLQ C30-score:in the overall level of health,all the function dimension,physical function,role function,emotional function,cognitive function,social function,fatigue,diarrhea differences statistically significant(P<0.05),quality of life of patients with major anterior resection syndrome significantly worse.Age,the distance between the lower margin of the tumor and the anal margin,and radiotherapy were risk factors for major anterior resection syndrome after anterior resection of rectal cancer(P<0.05),but none of them were independent risk factors(P>0.05).Conclusion The quality of life of patients after anterior resection is closely related to the occurrence of anterior resection syndrome,and the quality of life of patients with major anterior resection syndrome is poor.Patients with advanced age,low anastomotic site and radiation therapy are more likely to develop major anterior resection syndrome.

Key words: rectal cancer, anterior resection, quality of life, related factors

[1] 肖冉, 李菲, 邹贤军. 慢性血吸虫病与结直肠癌的相关性分析[J]. 临床外科杂志, 2019, 27(9): 779-781.
[2] 张鹏, 黄东, 刘全. 肠系膜下动脉高位与低位结扎合并根部淋巴结清扫在腹腔镜低位直肠癌根治术中的近期疗效对比[J]. 临床外科杂志, 2019, 27(9): 783-786.
[3] 邓文宏, 易斌, 邱振东, 项明伟, 何小波, 王卫星. 受体相互作用蛋白2在直肠癌中的表达及临床意义[J]. 临床外科杂志, 2019, 27(6): 489-491.
[4] 郝志楠, 莫波, 闵春明, 何磊. 腹腔镜直肠癌根治术中保留左结肠动脉对肠系膜下动脉3型直肠癌病人临床疗效及术后并发症的影响[J]. 临床外科杂志, 2019, 27(6): 492-494.
[5] 尤志军. 胃癌术后食管空肠RouxenY吻合与间置空肠代胃远期效果及对营养状况和生活质量的影响[J]. 临床外科杂志, 2019, 27(5): 390-393.
[6] 罗志民, 张家驹, 赵恩宏. 全身炎性反应与直肠癌术后生存率的相关分析[J]. 临床外科杂志, 2019, 27(5): 395-398.
[7] 张明府, 吴永丰, 柳东. 腹腔镜直肠癌前切除术中保留左结肠动脉对术后吻合口漏及近期疗效的影响[J]. 临床外科杂志, 2019, 27(5): 400-403.
[8] 高榕, 蒋生智, 何长春, 胡晓帆, 明智绪, 孙涛, 张庆华. 神经内镜经鼻蝶窦垂体瘤切除术后颅底重建对病人生活质量的影响[J]. 临床外科杂志, 2019, 27(2): 132-134.
[9] 黄丽丹, 周子筌, 刘莉, 付涛, 于红刚, 朱旭. 血清酶学指标对结直肠癌病人预后的预测价值[J]. 临床外科杂志, 2019, 27(12): 1044-1047.
[10] 杨正超, 陈治军, 张力, 冯艳坤. 不同麻醉方式对老年结直肠癌病人术后免疫功能及血清白细胞介素-6、肿瘤坏死因子-α水平的影响[J]. 临床外科杂志, 2019, 27(12): 1085-1087.
[11] 王磊, 颜登国. 老年结直肠癌病人围手术期手术危险因素分析[J]. 临床外科杂志, 2019, 27(11): 999-1001.
[12] 黄海涛, 王振军. 细胞减灭术和腹腔内热灌注化疗在结直肠癌腹膜转移的应用研究进展[J]. 临床外科杂志, 2019, 27(11): 1011-1013.
[13] 郑励力, 孙青芳, 卞留贯. 经蝶切除无功能垂体腺瘤对病人生活质量的影响[J]. 临床外科杂志, 2019, 27(10): 850-852.
[14] 朱旭, 刘莉, 于红刚. 炎症相关指标与结直肠癌预后的关系[J]. 临床外科杂志, 2019, 27(10): 873-875.
[15] 秦新裕, 许剑民, 任黎, 常文举. 2018版《中国结直肠癌肝转移诊断和综合治疗指南》解读[J]. 临床外科杂志, 2019, 27(1): 9-13.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!