Abstract: Objective  To evaluate the predictive factors associated with pathological complete response after preoperative neoadjuvant chemoradiotherapy for local advanced recta cancer.Methods  A retrospective analysis was performed on the clinical data of 88 patients with rectal cancer,who underwent neoadjuvant chemoradiotherapy fellowed by radical surgery，all patients received 48～50 Gy of radiotherapy,each 2GY,concurrent fluorouracilbased chemotherapy and then accepted radical surgery after 6～8 weeks,the clinical factors associated with pCR and nonpCR were analysed by logistic regression.results  Eightyeight patients were enrolled and 10 patients achieved pCR after operation.The pCR rate was 11.4%.Univariate analysis showed that the maximum tumor diameter,T stage,N stage,pathological type,pretreatment serum CEA level correlated with tumor pCR level.Multivariate analysis showed that N stage and pretreatment serum CEA level were the independent predictive factors affecting pCR after neoadjuvant chemoradiotherapy for rectal cancer.Conclusion Pretreatment clinical factors,such as low N staging and low serum CEA levels,may be associated with pCR after neoadjuvant chemoradiotherapy for rectal cancer.

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