临床外科杂志 ›› 2025, Vol. 33 ›› Issue (9): 981-984.doi: 10.3969/j.issn.1005-6483.20240902

• 论著 • 上一篇    下一篇

细胞周期蛋白B2、细胞周期蛋白E表达与肝癌病人临床病理特征及5年生存率的关系分析

方丽 田云霄 高庆利 牛广旭   

  1. 056000 河北邯郸，邯郸市中心医院病理科(方丽、田云霄、牛广旭)；馆陶县人民医院病理科(高庆利)
  • 收稿日期:2024-06-11 出版日期:2025-10-16 发布日期:2025-10-16

Relationship of the Cyclin B2 and Cyclin E1 expression with clinicopathological characteristics and 5-year survival rate of patients with hepatocellular carcinoma

FANG Li*,TIAN Yunxiao,GAO Qingli,NIU Guangxu   

  1. *Department of Pathology,Handan Central Hospital,Hebei,Handan 056000,China
  • Received:2024-06-11 Online:2025-09-20 Published:2025-10-16

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摘要： 目的 探讨细胞周期蛋白B2(CCNB2)、细胞周期蛋白E1(Cyclin E1)在肝细胞肝癌(HCC)中的表达及其对HCC预后判断的意义。方法 2013年10月~2016年10月收治的HCC病人60例，免疫组织化学法检测60例HCC组织及癌旁正常组织中CCNB2、Cyclin E1表达，分析二者与HCC病人临床病理特征之间的关系；Spearman法分析CCNB2、Cyclin E1表达相关性；Kaplan-Meier分析CCNB2、Cyclin E1表达与预后之间的关系；单变量和多变量Cox回归分析HCC病人预后的影响因素。结果 CCNB2、Cyclin E1在HCC组织的阳性表达率为61.67%、56.67%，明显高于癌旁正常组织的20.00%、13.33%，两组比较，差异有统计学意义（P<0.05)；CCNB2、Cyclin E1阳性表达与血清甲胎蛋白水平、肝硬化状态、癌栓和复发呈正相关(P<0.05)。HCC组织中CCNB2、Cyclin E1表达呈正相关(r=0.487，P=0.000)。HCC组织中CCNB2、Cyclin E1阳性表达预示着较低的生存期(χ2=7.104、7.140，P=0.008、0.008)。CCNB2、Cyclin E1阳性表达是影响HCC病人预后的独立因素(P<0.05)。结论 CCNB2、Cyclin E1在HCC中高表达，与血清AFP水平、肝硬化状态、癌栓和复发相关，并可作为独立的预后标志物。

关键词: 肝细胞肝癌；细胞周期蛋白B2；细胞周期蛋白E1；临床病理特征；预后

Abstract: Objective To investigate the expressions of cyclin B2(CCNB2) and cyclin E1(Cyclin E1) in hepatocellular carcinoma(HCC) and their significance for the prognosis of HCC.Methods Sixty HCC patients were admitted and treated from October 2013 to October 2016.The expressions of CCNB2 and Cyclin E1 in 60 HCC tissues and adjacent normal tissues were detected by immunohistochemistry,and the relationship between the two and the clinicopathological characteristics of HCC patients was analyzed;Spearman method was performed to analyze the correlation of CCNB2 and Cyclin E1 expression;Kaplan-Meier was performed to analyze the relationship between CCNB2,Cyclin E1 expression and clinical prognosis;and univariate and multivariate Cox regression were performed to analyze the influencing factors of clinical prognosis of HCC patients.Results The positive expression rates of CCNB2 and Cyclin E1 in HCC(61.67%,56.67%) were significantly higher than those in adjacent normal tissues(20.00%,13.33%,P<0.05);the positive expressions of CCNB2 and Cyclin E1 were positively correlated with serum AFP level,liver cirrhosis status,tumor thrombus and recurrence(P<0.05).The expressions of CCNB2 and Cyclin E1 in HCC tissues were positively correlated(r=0.487,P=0.000).The positive expressions of CCNB2 and Cyclin E1 in HCC tissues predicted a lower survival time(χ2=7.104,7.140,P=0.008,0.008).In addition,the positive expressions of CCNB2 and Cyclin E1 were independent factors affecting the prognosis of HCC patients(P<0.05).Conclusion CCNB2 and Cyclin E1 are highly expressed in HCC and are associated with serum AFP level,cirrhosis status,tumor thrombus and recurrence,and can be used as independent prognostic markers.

Key words: hepatocellular carcinoma;Cyclin B2;Cyclin E1;clinicopathological features;prognosis

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