临床外科杂志 ›› 2025, Vol. 33 ›› Issue (11): 1143-1147.doi: 10.3969/j.issn.1005-6483.20250551

• 论著 • 上一篇    下一篇

小儿单纯性硬膜外血肿保守治疗的疗效分析及血肿吸收预测模型构建

  

  1. 637000   四川南充,川北医学院附属医院小儿外科(冯松林、邓琳、赵丹、何文飞),神经外科(张涛)
  • 收稿日期:2025-05-27 接受日期:2025-05-27 出版日期:2025-11-20 发布日期:2025-11-20
  • 通讯作者: 张涛,Email:15281789915@163.com
  • 基金资助:
    基金项目:四川省医学会课题(编号S21059)

Analysis of the therapeutic effect of conservative treatment for simple epidural hematoma in children and Construction of hematoma absorption prediction model

  1. Department of Pediatric Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China
  • Received:2025-05-27 Accepted:2025-05-27 Online:2025-11-20 Published:2025-11-20

摘要: 目的 分析小儿单纯性硬膜外血肿(SEDH)保守治疗的临床效果及建立血肿吸收预测模型。方法  2023年8月~2025年3月行保守治疗的SEDH患儿218例。依据保守治疗后血肿吸收状况分为血肿吸收慢组(82例)和血肿吸收快组(136例)。比较两组患儿临床资料。Logistic回归分析影响保守治疗SEDH患儿血肿吸收的危险因素。构建基于保守治疗SEDH患儿血肿吸收预测的列线图模型,并用Bootstrap法进行内部验证,分析风险列线图模型对保守治疗SEDH患儿血肿吸收的预测效能。结果 伤后21天,血肿吸收速度<0.62ml/d 82例(37.61%,82/218)。血肿吸收慢组年龄为(10.43±1.93)岁、血肿体积为(22.09±3.96)ml、血肿最大厚度(5.92±1.48)mm、入院时格拉斯格昏迷评分(GCS)为(13.33±0.55)分,活化部分凝血酶时间为(30.96±8.94)秒,纤维蛋白原为(2.14±0.58)g/L;吸收快组分别为(7.60±1.53)岁、(12.30±4.13)ml、(3.18±1.06)mm、(14.48±0.48)分、(28.63±7.46)秒和(2.33±0.62)g/L,两组比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄、血肿体积、血肿最大厚度是影响保守治疗SEDH患儿血肿吸收的危险因素(P<0.05)。依据多因素分析结果构建列线图模型,校正曲线表明该模型拟合度较好。列线图模型预测SEDH患儿血肿吸收的灵敏度为89.02%(95%CI:79.71%~94.55%),特异度为91.91%(95%CI:85.65%~95.69%),曲线面积(AUC)为0.958(95%CI:0.923~0.981)。结论 基于年龄、血肿体积、血肿最大厚度因素构建的列线图模型,对SEDH患儿血肿吸收的预测效能较好。

关键词: 小儿, 单纯性硬膜外血肿, 保守治疗, 临床效果, 血肿吸收, 列线图, 预测模型

Abstract: Objective  To analyze the clinical effect of conservative treatment of 218 cases of simple epidural hematoma (SEDH) in children and establish the prediction model of hematoma absorption.Methods The clinical data of 218 children with SEDH who were treated conservatively in our hospital from August 2023 to March 2025 were analyzed retrospectively.According to the status of hematoma absorption after conservative treatment,the patients were divided into slow hematoma absorption group (n=82) and fast hematoma absorption group (n=136).The clinical data of children with slow hematoma absorption group and fast hematoma absorption group were compared.Logistic regression analysis was used to explore the risk factors of hematoma absorption in children with conservative treatment of SEDH.A nomogram model based on the prediction of hematoma absorption in children with SEDH treated conservatively was constructed and verified internally by Bootstrap method.To analyze the predictive efficacy of risk nomogram model for hematoma absorption in children with SEDH treated conservatively.Results 21 days after injury,37.61%(82/218) of SEDH patients had a hematoma absorption rate of < 0.62ml/d after conservative treatment.The  slow hematoma absorption  group had an average age of (10.43±1.93)years,hematoma volume of (22.09±3.96 )ml,maximum hematoma thickness of (5.92±1.48) mm,admission Glasgow Coma Scale (GCS) score of (13.33±0.55),activated partial thromboplastin time (APTT) of (30.96±8.94) seconds,and fibrinogen level of (2.14 ± 0.58 )g/L.In contrast,the fast absorption group showed corresponding values of (7.60±1.53 )years,(12.30±4.13 )ml,(3.18±1.06) mm,(14.48±0.48),(28.63±7.46) seconds,and (2.33±0.62 )g/L.The differences between the two groups were statistically significant (P<0.05).Logistic regression analysis identified age,hematoma volume,and maximum hematoma thickness as risk factors influencing hematoma absorption (P<0.05).According to the results of multi-factor analysis,the nomogram model was constructed,and the calibration curve shows that the model has good fitting degree.The sensitivity of the nomogram model for predicting hematoma absorption in children with SEDH was 89.02% (95%CI:79.71%94.55%),the specificity was 91.91% (95%CI:85.65%~95.69%),and the area under curve (AUC) was 0.958 (95%CI:0.923~0.981).Conclusion The nomogram model based on factors such as age,hematoma volume,and maximum hematoma thickness of hematoma has a good predictive effect on hematoma absorption in SEDH children.

Key words: children, simple epidural hematoma, conservative treatment, clinical effect, hematoma absorption, nomogram, prediction model

[1] 孙磊 杨玉亭 李朝辉. 胫骨平台伴髁间棘骨折病人术后关节功能恢复的影响因素及其预测效能研究[J]. 临床外科杂志, 2025, 33(9): 992-996.
[2] 徐锋 周心奇 高健扬. 腹腔镜直肠癌术后发生排尿功能障碍的危险因素分析及风险预测模型构建[J]. 临床外科杂志, 2025, 33(8): 813-817.
[3] 王青峰 陆晶晶 鲁生林 汪源 吴永丰 张明府. 甲状腺癌术中甲状旁腺损伤的影响因素分析及预测模型构建[J]. 临床外科杂志, 2025, 33(8): 832-835.
[4] 潘青 牛一聪 陈诚 马大昌 武君. 乳腺癌新辅助化疗后前哨淋巴结转移完全缓解的预测模型构建[J]. 临床外科杂志, 2025, 33(8): 846-851.
[5] 刘耀华 侯秀秀 赵玲 王赛 魏娜 张文宝. 老年股骨粗隆间骨折髓内钉内固定术后3年病情转归的预测模型构建与检验[J]. 临床外科杂志, 2025, 33(8): 870-874.
[6] 李翔 周林秋 李珺 佘晶江 许剑 段建春 李玉文. 腹腔镜直肠癌根治术病人术后胃肠功能影响因素分析[J]. 临床外科杂志, 2025, 33(7): 730-.
[7] 黄晓科 汤庆峰 赖维奇 朱江 钟远友 胡小波 杨仕伟. 基质GLA蛋白与特发性草酸钙结石影响因素的关联及预测模型构建[J]. 临床外科杂志, 2025, 33(7): 757-.
[8] 邵辉 王璐 汤洁莹 陈强 张世红 侯亦康 徐鑫宇 杨建民 李薇薇. 经乳晕小切口联合吸脂术治疗男性乳房发育症[J]. 临床外科杂志, 2025, 33(7): 767-.
[9] 彭伟生, 杨毅, 杨翠婷, 王成立, 何桂凤, 郑宇强, 黄莹. 基于增强CT影像组学特征和参数诊断胃腺癌术前淋巴结转移的列线图预测模型[J]. 临床外科杂志, 2025, 33(4): 405-409.
[10] 潘均昊, 王春晖. 基于SEER数据库构建远处转移性肝细胞癌的预后预测模型[J]. 临床外科杂志, 2025, 33(4): 410-415.
[11] 王怡凤 华荣 何毅. 老年食管癌病人术后并发症Clavien-Dindo分级≥Ⅲ级的影响因素及列线图预测模型构建[J]. 临床外科杂志, 2025, 33(3): 261-266.
[12] 舒凯 雷霆. 综合医院小儿神经外科的建设:现状、挑战与未来展望[J]. 临床外科杂志, 2025, 33(11): 1121-1123.
[13] 王潇文 邱天明 朱巍. 常见小儿脑血管病的诊治[J]. 临床外科杂志, 2025, 33(11): 1129-1132.
[14] 陈义初 魏磊 汪力 皮名安 龚立. 机器人辅助在小儿纵隔肿瘤切除术中的应用——单中心99例分析[J]. 临床外科杂志, 2025, 33(11): 1155-1158.
[15] 庞燕 刘杰 吴春莹. 铁死亡相关基因表达水平与乳腺癌病人新辅助化疗反应性的相关性[J]. 临床外科杂志, 2025, 33(11): 1175-1179.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 黄洪锋. 关注公民逝世后器官捐献肾移植受体围手术期感染的预防与处理[J]. 临床外科杂志, 2016, 24(10): 732 .
[2] 杨华;李新长;龙成美;等. 公民逝世后器官捐献供肾移植临床分析[J]. 临床外科杂志, 2016, 24(10): 747 .
[3] 石宇;刘学刚 . 冠状动脉旁路移植术后短期内应用强化他汀对患者出血风险的研究[J]. 临床外科杂志, 2016, 24(10): 750 .
[4] 陈忠;王耀东;田毅峰;等. 肝胆管结石病规范化治疗的临床分析[J]. 临床外科杂志, 2016, 24(10): 753 .
[5] 阿布力克木·毛拉尤甫;郑秉礼. 胰腺实性假乳头状瘤45例手术治疗分析[J]. 临床外科杂志, 2016, 24(10): 764 .
[6] 李光焰;张安平;王祥峰;等. 直肠癌切除术后吻合口狭窄14例分析[J]. 临床外科杂志, 2016, 24(10): 772 .
[7] 胡小平;王志维;邓宏平;等. 改良全主动脉弓置换治疗老年Stanford A型主动脉夹层[J]. 临床外科杂志, 2016, 24(10): 777 .
[8] 戴强;徐康;周治军;等. 湖北天门地区泌尿系结石成分及特征分析[J]. 临床外科杂志, 2016, 24(10): 789 .
[9] 胡光俊;宋晓阳;陶军. 右美托咪定添加到罗哌卡因中对腰丛坐骨神经阻滞及镇静的影响[J]. 临床外科杂志, 2016, 24(10): 796 .
[10] 陈海滨;吕松岑. 全膝关节置换术术中止血药物的应用策略[J]. 临床外科杂志, 2016, 24(10): 800 .