关键词: 非生殖细胞瘤性生殖细胞肿瘤, 中枢神经系统肿瘤, 儿童, 综合治疗

Abstract: Pediatric intracranial non-germinoma Tous germ cell tumors (NGGCTs) are a group of rare,highly heterogeneous malignant tumors,encompassing subtypes such as immature teratoma,embryonal carcinoma,yolk sac tumor,choriocarcinoma,and mixed germ cell tumors.The management of NGGCTs requires the integration of multidisciplinary approaches including surgery,chemotherapy,and radiotherapy;however,significant controversies persist regarding treatment sequence,surgical timing,and the selection of chemoradiotherapy regimens.Currently,most international mainstream strategies recommend platinum-based chemotherapy combined with postoperative radiotherapy.In contrast,Asian researchers have proposed an individualized surgery-prioritized strategy based on clinical practice,emphasizing that tumors containing teratomatous components or measuring ≤3 cm should undergo direct surgical resection.

Key words: non-germinoma Tous germ cell tumor, central nervous system tumor, child, multimodal therapy