关键词: 三阴性乳腺癌； 环状RNA, 分子靶点； 生物标志物

Abstract: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death for female in the world.Triple negative breast cancer (TNBC) among its molecular subtypes has become a difficult point in breast cancer treatment due to the lack of clear molecular targets.The first aim for targeted therapy of TNBC is to find reliable biomarkers to identify TNBC.The research of TNBC-related non-coding RNA markers has become a hot spot in this field.Circular RNA (circular RNA,circRNA) is an important type of non-coding RNA，since many researches have indicated that circRNAs play a vital role in many life process like cellular structure and function,gene expression and regulation,signal pathway and particular in the occurrence and development of cancer.In recent years,many literatures have reported circRNA related to the occurrence and development of TNBC and explained its molecular mechanism,some of which can also be used as TNBC biomarkers.This article will review related researches.

Key words: triple-negative breast cancer, circular RNA, molecular targets, biomarkers