前列腺增生合并中重度膀胱过度活动行经尿道前列腺电切术后早期应用索利那新的效果研究

doi:10.3969/j.issn.1005-6483.2021.10.022

摘要/Abstract

摘要： 目的探讨前列腺增生合并中重度膀胱过度活动的病人在经尿道前列腺电切(TURP)术后早期应用索利那新的合理性。
方法对127例术前诊断为前列腺增生且膀胱过度活动症症状评分表(OABSS)评分>5分的病人行TURP术后进行前瞻性评估,根据OABSS分为两组。术前OABSS评分为重度(≥11分)者为G1组,OABSS评分为中度(≤10分)者为G2组。此外,每组病人被随机进一步分为两个亚组:在术后早期使用索利那新治疗的(G1A/G2A)组和未进行治疗的(G1B/G2B)组,术后3个月再次进行OABSS评分,观察索利那新在TURP术后早期应用的合理性。
结果术前OABSS评分:G1A组11.63±1.149,G1B组12.43±1.165,G2A组6.41±1.142,G2B组6.30±1.311;术后3个月OABSS评分:G1A组5.26±1.196,G1B组7.63±2.092,G2A组5.57±2.940,G2B组4.55±2.862。G1组与G2组术后3个月OABSS评分比较差异有统计学意义(P<0.05);G1A和G1B之间比较差异均有统计学意义(P<0.05),但G2A和G2B之间比较差异无统计学意义(P>0.05)。
结论在术前OABSS评分为重度的病人中开始术后早期索利那新治疗是合理的。

关键词: 前列腺增生, 膀胱过度活动, 经尿道前列腺电切术, 索利那新

Abstract: Objective To investigate starting early solifenacin treatment in patients with high preoperative OABSS after transurethral resection of the prostate(TURP) would be reasonable.
Methods A total of 127patients(OABSS score>5) undergoing TURP were prospectively evaluated and divided into two groups according to their OABSS.Those with a score of ≥11 points were Group 1(G1),and those with ≤10 points Group 2(G2).In addition,patients in each group were randomly further divided into two subgroups:those who were started on 5 mg solifenacin succinate in the earlypostoperative period(G1A/G2 A) and those who were not(G1B/G2B).
Results Preoperative OABSS score:G1A group 11.63±1.149,G1B group 12.43±1.165,G2A group 6.41±1.142,G2B group 6.30±1.311;OABSS score in three months after operation:G1A group 5.26±1.196,G1B group 7.63±2.092,G2A Group 5.57±2.940,G2B group 4.55±2.862;G1 group and G2 group three months after the OABSS score comparison P=0.007(P<0.05);G1A and G1B comparison P<0.001,G2A and G2B comparison P=0.138(P>0.05).
Conclusion Solifenacin succinate treatment in the early postoperative period may be beneficial for patients with high preoperative OABSS.

Key words: benign prostatic hyperplasia, overactive bladder, transurethral resection of the prostate, Solifenacin

刘乐冯春青周洪革. 前列腺增生合并中重度膀胱过度活动行经尿道前列腺电切术后早期应用索利那新的效果研究[J]. 临床外科杂志, 2021, 29(10): 976-978.

LIU Le, FENG Chunqing, ZHOU Hongge.. Study on the effect of early application of Solinasine after TURP in patients with benign prostatic hyperplasia and moderate to severe overactive bladder[J]. JOURNAL OF CLINICAL SURGERY, 2021, 29(10): 976-978.

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