临床外科杂志 ›› 2020, Vol. 28 ›› Issue (12): 1144-1146.doi: 10.3969/j.issn.1005-6483.2020.12.016

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结直肠癌病人miR-21、血管内皮生长因子、基质金属蛋白酶-9表达与临床特征及预后的相关性

  

  1. 442200 湖北十堰,湖北医药学院附属人民医院胃肠外科
  • 出版日期:2020-12-20 发布日期:2020-12-20
  • 通讯作者: 李玉梅,Email:323201749@qq.com

Correlation between expression of miR-21,VEGF and MMP-9 and prognosis in patients with colorectal cancer

  1. Department of Gastrointestinal Surgery,Renmin Hospital of Hubei University of Medicine,Hubei,Shiyan 442200,China
  • Online:2020-12-20 Published:2020-12-20

摘要: 目的 探讨结直肠癌病人miR-21、血管内皮生长因子(vascular endothelial growth factor,VEGF)、基质金属蛋白酶(matrix metalloproteinase,MMP)-9表达与临床特征及预后的相关性。
方法 2013年12月~2016年6月我院收治的结直肠癌病人144例,检测miR-21、VEGF、MMP-9在肿瘤组织中的表达情况,分析其与临床病理特征及预后的相关性。
结果 肿瘤组织miR-21、VEGF、MMP-9表达阳性率分别为72.9%、69.4%和84.0%,显著高于非肿瘤组织的15.3%、23.6%和38.9%,差异有统计学意义(P<0.05)。在144例病人中,肿瘤组织miR-21、VEGF、MMP-9的表达阳性与肿瘤分化程度、淋巴结转移、临床分期、肿瘤直径密切相关(P<0.05)。随访至2019年10月,死亡34例,死亡率为23.6%,COX回归模型分析,结果显示,miR-21、VEGF、MMP-9等是影响结直肠癌病人预后的因素(P<0.05)。
结论 结直肠癌病人伴随miR-21、VEGF、MMP-9的高表达,与病人的病理特征显著相关,且miR-21、VEGF、MMP-9可影响病人的预后。

关键词: 结直肠癌, miR-21, 血管内皮生长因子, 基质金属蛋白酶-9

Abstract: Objective To investigate the relationship between the expression of miR-21,vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 and prognosis in patients with colorectal cancer.
Methods From December 2013 to June 2016,144 cases of patients with colorectal cancer were enrolled in this hospital.All patients were underwent endoscopic radical surgery,and the clinicopathological features were investigated.The prognosis were followed up and given correlation analysis.
Results The positive rates of miR-21,VEGF and MMP-9 in the lesion group were 72.9%,69.4% and 84.0%,which were significantly higher than those in the control group (15.3%,23.6% and 38.9%) (P<0.05).In the 144 patients,the positive expression of miR-21,VEGF and MMP-9 in the lesions were closely related to tumor differentiation,lymph node metastasis,clinical stage and tumor diameter (P<0.05).Follow-up to October 2019,there were 34 patients were deaths that the mortality rates were 23.6%,COX regression model showed that miR-21,VEGF,MMP-9 are the factors that affected the prognosis of colorectal cancer patients (P<0.05).
Conclusion The high expression of miR-21,VEGF and MMP-9 in patients with colorectal cancer are significantly correlated with the pathological features of patients,and miR-21,VEGF and MMP-9 may affect the prognosis of patients.

Key words: colorectal cancer, miR-21, vascular endothelial growth factor, matrix metalloproteinase-9

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