关键词: 动脉瘤性蛛网膜下腔出血, 可溶性血小板衍生生长因子受体β, 认知功能, 生物标志物

Abstract: Objective   To investigate the relationship between the level of soluble platelet-derived growth factor receptor β(sPDGFRβ) in cerebrospinal fluid and cognitive impairment in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods   Cerebrospinal fluid samples from 55 aSAH patients within 72 hours and 20 controls were collected prospectively,and the concentration of sPDGFRβ in cerebrospinal fluid was detected by ELISA.Six months after discharge,aSAH patients were followed up by outpatient visit or telephone,and the cognitive function was evaluated by the Mini-Mental State Examination or the Telephone Interview for Cognitive Status-Modified. Results   The concentration of sPDGFRβ in cerebrospinal fluid was (1.076±0.353)ng/ml in aSAH group and (0.574±0.057)ng/ml in control group,and there was a statistically significant difference between the two groups (P<0.05).Among 55 aSAH patients,19 suffered from cognitive impairment.The concentration of sPDGFRβ in cerebrospinal fluid of patients with cognitive impairment [(1.387±0.280)ng/ml] was significantly higher than that of patients without cognitive impairment [(0.911±0.268)ng/ml] (P<0.05).Multivariate regression analysis showed that Hunt-Hess grade Ⅳ~Ⅴ and sPDGFRβ≥1.347ng/ml were independent risk factors for cognitive impairment in aSAH patients 6 months after discharge (P<0.01). Conclusion   The level of sPDGFRβ in cerebrospinal fluid increases after aSAH,associated with cognitive impairment in patients.

Key words: aneurysmal subarachnoid hemorrhage, platelet-derived growth factor receptor β, cognitive function, biomarkers