临床外科杂志 ›› 2022, Vol. 30 ›› Issue (10): 958-962.doi: 10.3969/j.issn.1005-6483.2022.10.017

• 论著 • 上一篇    下一篇

基于SEER数据库的年轻和老年甲状腺未分化癌的比较研究

  

  1. 200233,上海交通大学医学院附属第六人民医院普外科
  • 收稿日期:2021-11-09 修回日期:2021-11-09 出版日期:2022-10-20 发布日期:2022-10-20
  • 通讯作者: 郭明高,Email:guominggao203@163.com

A comparative study of elderly and younger patients with anaplastic thyroid cancer based on SEER database

  1. Department of General Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233,China
  • Received:2021-11-09 Revised:2021-11-09 Online:2022-10-20 Published:2022-10-20

摘要: 目的 比较老年组(年龄≥60 岁)和年轻组(年龄<60 岁)甲状腺未分化癌(ATC)病人的临床病理特征和生存结果。方法 从SEER数据库筛选出1998~2016年间诊断为ATC病人516例,并分为老年组(391例)和年轻组(125例)。比较两组病人特征差异,采用比例风险模型分析年龄与死亡风险的关系,最后在肿瘤分期亚组中分析老年组和年轻组死亡风险的差异。结果 单因素分析显示,年轻组接受放疗(75.9%vs.55.5%) 和化疗(66.7%vs.39.5%)人群比例更高。年轻组的总生存率(OS)和肿瘤特异性生存率(CSS)更高,两组比较差异有统计学意义(P< 0.05)。多因素Cox回归分析显示,年龄<60岁(OS:HR=0.69,95%CI=0.56~0.86,P=0.001;CSS:HR=0.73,95%CI=0.59~0.92,P=0.007)是预后的独立有利因素(P<0.05)。〖H结论 老年ATC病人较年轻ATC人预后更差,年龄是ATC独立预后因素。

关键词: 未分化甲状腺癌, SEER数据库, 年龄, 比较

Abstract: Objective To compare the clinicopathological characteristics and survival outcomes of elderly(≥60 years old) and younger(<60 years old) patients with anaplastic thyroid cancer(ATC).Methods The information about clinicopathological characteristics and prognostic in patients with diagnosed ATC was from 1998~2016 was extracted from the Surveillance,Epidemiology,and End Results(SEER) database.A total of 516 eligible patients and divided into the elderly group(n=391) and the younger group(n=125).Compared the clinicopathological characteristics between the two groups by using chi-square test.The Kaplan-Merrier and Cox regression methods were used to determine the prognostic factors of ATC.Finally,analyzed the mortality risk of two groups in the tumor staging subgroups.Results The younger group was more likely to receive radiotherapy(75.9% vs.55.5%) and chemotherapy(66.7% vs.39.5%).In addition,the specific survival rate and overall survival rate of young patients were significantly higher(P<0.05).Multivariate Cox regression analysis revealed that age<60-years-old was significantly associated with the better prognosis(OS:HR=0.69,95%CI=0.56~0.86,P=0.001;CSS:HR=0.73,95%CI=0.59~0.92,P=0.007).And age<60-year-old was an independent predictor of prognosis in ATC patients with distant metastasis.Conclusion The prognosis of elderly ATC patients is worse than that in younger patients and age may be a prognostic factor for anaplastic thyroid cancer.

Key words: anaplastic thyroid cancer, SEER database, age, comparison

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