MRI定量增强参数与乳腺癌预后因子及分子分型的相关性及其临床应用

doi:10.3969/j.issn.1005-6483.2019.10.011

摘要/Abstract

摘要： 目的探究MRI定量增强参数与乳腺癌预后因子及分子分型的相关性及其临床应用。方法 2016年8月～2017年8月在我院治疗的乳腺癌病人126例，根据不同影像学检查方式分为对照组（行CT检查）和研究组（行MRI检查），每组各63例。对两组病人的临床资料行回顾性分析。结果研究组诊断方法的敏感性和准确率高于对照组（P<0.05），雌激素受体显示阳性的病人的容量转移常数值、速率常数高于雌激素受体显示阴性（P<0.05）。Luminal A型、Luminal B型的容量转移常数以及速率常数小于人类表皮生长因子受体-2过表达型、TNBC型（P<0.05），但Luminal A型、LuminalB型的血管外细胞外间隙容积比大于TNBC型（P<0.05），其中Luminal B型的血管外细胞外间隙容积比最高，而TNBC型的速率常数最高。结论通过MRI定量增强参数对乳腺癌的预后以及分子分型具有一定的提示作用，与雌激素受体具有一定相关性，而与人类表皮生长因子受体2的相关性不大。

关键词: MRI定量增强参数, 乳腺癌预后因子, 分子分型, 相关性

Abstract: Objective To explore the correlation between MRI quantitative enhancement parameters and prognostic factors and molecular typing of breast cancer and its clinical application.Methods This study was a retrospective study.126 patients with breast cancer who were treated in our hospital from August 2016 to August 2017 were selected.According to different imaging methods，the control group（CT examination）and the research group（MRI examination）were 63 cases each.Retrospective analysis of clinical data of two groups.Results The sensitivity and accuracy of the diagnostic method in the study group were significantly higher than those in the control group（P<0.05）.The volume transfer constant and rate constant of patients with positive estrogen receptors were significantly higher than those of negative estrogen receptors（P<0.05）.The volume transfer constants and rate constants of Luminal type A and Luminal type B were significantly smaller than those of HER-2 overexpression type and TNBC type（P<0.05），but the volume ratio of extravascular extracellular space of Luminal type A and Luminal type B was significantly larger than that of TNBC type.（P<0.05），in which Luminal B type had the highest extravascular extracellular space volume ratio，while TNBC type had the highest rate constant.Conclusion Quantitative enhancement parameters of MR imaging have certain implications for the prognosis and molecular typing of breast cancer，and have certain correlation with estrogen receptor，but not with human epidermal growth factor receptor-2，which is worthy of clinical promotion.

Key words: MRI quantitative enhancement parameters, breast cancer prognostic factors, molecular typing, correlation

涂俊, 瞿广桥. MRI定量增强参数与乳腺癌预后因子及分子分型的相关性及其临床应用[J]. 临床外科杂志, 2019, 27(10): 859-861.

TU Jun, QU Guangqiao.. Correlation between MRI quantitative enhancement parameters and prognostic factors and molecular typing of breast cancer and its clinical application[J]. JOURNAL OF CLINICAL SURGERY, 2019, 27(10): 859-861.

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