临床外科杂志 ›› 2019, Vol. 27 ›› Issue (8): 694-696.doi: 10.3969/j.issn.1005-6483.2019.08.021

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左卡尼汀联合经尿道精囊镜下扩张射精管对梗阻性无精症的应用效果及预后分析

  

  1. 430060 武汉市第三医院泌尿外科
  • 出版日期:2019-08-20 发布日期:2019-08-20
  • 通讯作者: 张景宇,Email:344649225@qq.com

L-carnitine combined with transurethral seminal endoscopic dilatation of the ejaculatory duct effect analysis of obstructive azoospermia and prognosis

  1. Department of Urology,the Third People's Hospital of Wuhan City,Wuhan 430060,China
  • Online:2019-08-20 Published:2019-08-20

摘要: 目的 探讨左卡尼汀联合经尿道精囊镜下扩张射精管对梗阻性无精症的应用及预后效果。方法 梗阻性无精症病人40例。按照简单随机法将病人分为对照组、观察组,每组20例,均行经尿道精囊镜下扩张射精管术。术后对照组予以口服维生素E,观察组予以口服左卡尼汀。比较两组治疗效果,治疗前后活动精子率、前向运动精子率,以及术后配偶妊娠情况。结果 对照组治疗有效率为60.00%,观察组为80.00%,差异有统计学意义(P<0.05)。两组治疗后活动精子率、前向运动精子率均高于治疗前,观察组病人治疗后活动精子率、前向运动精子率优于对照组,差异有统计学意义(P<0.05)。对照组治疗后12例(60.00%)检出精子,观察组18例(90.00%)检出精子;观察组配偶临床妊娠及活产婴儿均高于对照组,差异有统计学意义(P<0.05)。结论 左卡尼汀联合经尿道精囊镜下扩张射精管对梗阻性无精症临床效果显著,可改善无精症,同时改善治疗后的妊娠结局。

关键词: 左卡尼汀, 尿道精囊镜, 扩张射精管术, 梗阻性无精症

Abstract: Objective To investigate the L-carnitine combined with transurethral seminal endoscopic dilatation of the ejaculatory duct effect analysis of obstructive azoospermia and prognosis.Methods 40 cases of patients with obstructive azoospermia were studied in our hospital.According to the simple random method were divided into control group and observation group,20 cases in each group.Patients underwent transurethral seminal endoscopic dilatation of the ejaculatory duct after operation,the control group was given oral vitamin E,observation group received oral l-carnitine.The therapeutic effect,active sperm rate,forward motile sperm rate,TNF- alpha,ROS level,and pregnancy status of the spouses of the two groups were compared before and after treatment.Results The effective rate of the control group was 60%,and the effective rate of the observation group was 80%.The treatment effect of the observation group was significantly better than that of the control group(P<0.05).After treatment,two groups of patients with active sperm rate,forward movement sperm rate were higher than before treatment(P<0.05); the observation group after treatment of active sperm rate,forward movement sperm rate was significantly better than the control group(P<0.05).The two groups of patients with follow-up,patients in the control group after treatment,12 cases(12/20,60%) detection of sperm after treatment in the observation group were 18 cases(18/20,90%) detection of sperm; observation group of spouses of patients with clinical pregnancy and live births were higher than the control group(P<0.05).Conclusion Therapeutic effect of L-carnitine combined with transurethral seminal endoscopic dilatation of ejaculatory duct obstructive azoospermia significantly,can effectively improve the patients with azoospermia,and improve the outcome of pregnancy after treatment.

Key words: Lcarnitine;urethral seminal vesicle , mirror;dilation of ejaculatory duct;obstructive azoospermia

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