临床外科杂志 ›› 2019, Vol. 27 ›› Issue (7): 581-584.doi: 10.3969/j.issn.1005-6483.2019.07.013

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干扰素诱导跨膜蛋白3、半乳糖凝集素-7和半乳糖凝集素-9表达与胸中段食管鳞癌改良Ivor lewis术后淋巴结转移性复发的关系

  

  1. 中国人民解放军联勤保障部队第九六○医院胸外科
  • 出版日期:2019-07-20 发布日期:2019-07-20

The expression of IFITM3,Galectin-7,Galectin-9 of midthoracic esophageal squamous cell carcinoma and relationship with lymphatic metastatic recurrence after modified Ivor lewis esophagectomy

  • Online:2019-07-20 Published:2019-07-20

摘要: 目的:探讨胸中段食管鳞癌(ESCC)干扰素诱导跨膜蛋白3(IFITM3)、半乳糖凝集素7(Galectin7)和Galectin9表达及与改良Ivorlewis术后淋巴结转移性复发的关系。方法:改良Ivorlewis手术治疗的胸中段食管癌病人91例,采用免疫组织化学法(IHC)检测肿瘤组织及癌旁正常组织中IFITM3、Galectin7、Galectin9表达情况,并分析其与术后淋巴结转移性复发的关系。结果:ESCC病灶组织中IFITM3、Galectin7表达量高于癌旁组织,Galectin9表达量低于癌旁组,差异有统计学意义(P<0.05);ESCC病灶组织中IFITM3、Galectin7、Galectin9阳性表达率分别为57.14%、65.93%和60.44%,癌旁组织分别为13.19%、5.49%和89.01%,两组比较差异有统计学意义(P<0.05)。随着TNM分期的升高,IFITM3、Galectin7的阳性表达率也明显升高(P<0.05)。术后3年内有37例(40.66%)淋巴结复发性转移,TNM分期、IFITM3和Galectin7过表达、Galectin9欠表达是淋巴结转移性复发的独立危险因素(P<0.05)。结论:IFITM3、Galectin7过表达和Galectin9欠表达参与了胸中段ESCC的发生及发展,且与改良Ivorlewis术后淋巴结转移性复发密切相关。

关键词: 食管鳞癌, 改良Ivorlewis手术, 淋巴转移复发, 干扰素诱导跨膜蛋白3, 半乳糖凝集素

Abstract: Objective:To investigate the expression of interferoninduced transmembrane protein 3(IFITM3),Galectin7 and Galectin9 of midthoracic esophageal squamous cell carcinoma(ESCC)and relationship with lymphatic metastatic recurrence after modified Ivorlewis esophagectomy.Methods:91 patients with midthoracic ESCC underwent modified Ivorlewis esophagectomy with twofield lymphadenectomy were enrolled,the expression profile of IFITM3,Galectin7,Galectin9 protein of samples of the ESCC tissues and paracarcinoma tissues were detected by immunohistochemistry(IHC),the relationship of IFITM3,Galectin7,Galectin9 expression and lymphatic metastatic recurrence was analyzed.Results:The expression of IFITM3 and Galectin7 in samples of ESCC tissues was significantly higher than the paracarcinoma tissues,while the expression of Galectin9 was significantly lower than the paracarcinoma tissues,the  differences were statistically significant(P<0.05).The positive expression rate of IFITM3,Galectin7,Galectin9 in samples of ESCC tissues was 57.14%,65.93% and 60.44%,respectively;and the positive expression rate was 13.19%,5.49% and 89.01% in samples of paracarcinoma tissues,respectively.Tthe difference was statistically significant(P<0.05).With the increase of TNM stage,the positive expression rates of IFITM3 and Galectin7 were significantly increased(P<0.05).There was 37 patients(40.66%)with lymphatic metastatic recurrence within 3 years after surgery,the TNM stage,IFITM3 and Galectin7 overexpression,and Galectin9 underexpression were independent risk factors forymphatic metastatic recurrence(P<0.05).Conclusion:IFITM3,Galectin7 overexpression and Galectin9 underexpression might involve in occurrence and development of the midthoracic ESCC.It may be closely related to improved lymph node metastasis after Ivorlewis surgery.

Key words: esophageal squamous cell carcinoma, modified Ivorlewis esophagectomy, lymphatic metastatic recurrence, interferoninduced transmembrane protein 3, galectin

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