临床外科杂志 ›› 2019, Vol. 27 ›› Issue (6): 480-482.doi: 10.3969/j.issn.1005-6483.2019.06.011

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羟考酮对舌癌术后病人留置气管导管耐受性的临床观察

  

  1. 430030 武汉,华中科技大学同济医学院附属同济医院麻醉科
  • 出版日期:2019-06-20 发布日期:2019-06-20
  • 通讯作者: 江辉,Email:jianghui0429@aliyun.com

The investigation of oxycodone on tracheal catheter tolerance in patients with tongue cancer after general anesthesia

  1. Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
  • Online:2019-06-20 Published:2019-06-20

摘要: 目的 观察羟考酮用于舌癌病人全麻手术后清醒期对气管导管耐受的临床疗效。方法 舌癌根治性手术病人90例,随机分成Q组、S组和Y组三组,每组各30例,均行常规麻醉诱导和麻醉维持。Q组于手术结束前30分钟静注羟考酮0.1mg/kg、S组用舒芬太尼0.1μg/kg,Y组用生理盐水5ml。观察三组镇静躁动评分、术毕清醒期的呛咳次数和血流动力学变化及不良反应发生率。结果 与Y组比较,Q、S组病人术毕不同时间点血流动力学变化更平稳(P<0.05);Q组和S组镇静-躁动评分分别为(4.1±0.2)分和(4.2±0.3)分,Y组为(5.7±0.3)分,Q组、S组与Y组比较差异有统计学意义(P<0.05);Q、S组的呛咳次数均显著少于Y组(P<0.05),且Q组病人术后6小时内呛咳次数为(2.1±0.6)次,与S组(3.6±1.3)比较有所减少(P<0.05);Y组、Q组、S组三组不良反应发生例数分别为8例、10例和9例,差异无统计学意义(P>0.05)。结论 羟考酮相比舒芬太尼而言,能使舌癌病人术后更好地耐受气管导管。

关键词: 羟考酮, 舌癌, 气管导管耐受

Abstract: Objective To investigate the clinical effect of oxycodone on tracheal catheter tolerance during awake period after general anesthesia in patients with tongue cancer.Methods 90 patients with radical surgery for tongue cancer were randomly divided into three groups(Q group,S group and Y group),30 patients in each group,all under routine anesthesia induction and anesthesia maintenance.Oxycodone 0.1mg/kg(Q group),sulfentanil 0.1μg/kg(S group),and normal saline 5ml(Y group)were intravenously administered 30min before the end of the operation.The sedation-agitation score after recovery and the postoperative events(cough frequency,hemodynamic changes and adverse reaction)of the three groups of patients were quantified.Results The hemodynamic changes in Q group and S group were more stable than those in group Y(P<0.05);The sedation-agitation scores in Q group(4.1±0.2)and S group(4.2±0.3)were significantly lower than those in Y group(5.7±0.3)(P<0.05).And the postoperative cough frequency in the Q group and S group were both less than that in the Y group(P<0.05).The number of cough(2.1±0.6)in Q group within 6 hours after operation was reduced compared with that in S group(3.6±1.3)(P<0.05).There was no significant difference in the patient's adverse reactions(Y group:8 cases,Q group:10 cases,S group:9 cases)(P>0.05).Conclusion Oxycodone displayed improved effects compared to sulfentanil in reducing the number of postoperative coughs which makes the patient better tolerate the tracheal tube.

Key words: Oxycodone, tongue cancer, tracheal catheter tolerance

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