Abstract: Objective To analyze the relationship between serum forkhead box protein O1 (FOXO1) and myeloid cell trigger receptor 2 (TREM2) levels and brain edema volume and nerve function in patients with cerebral hemorrhage.Methods Clinical data of 150 patients with cerebral hemorrhage (test group) who received treatment in our hospital from January 2021 to January 2023 were retrospectively collected,and 60 healthy patients who came to our hospital for physical examination during the same period were selected as the control group.The levels of FOXO1 and TREM2 were compared between the two groups.Using the median FOXO1 and TREM2 as nodes,the patients were divided into high level and low level observation groups,and the differences of edema volume and National Institutes of Health Stroke Scale (NIHSS) scores were compared among different groups at admission,3 days after admission and 5 days after admission.Pearson analyzed the correlation of serum FOXO1 and TREM2 levels with edema volume and nerve function.Results The levels of FOXO1 and TREM2 in the observation group were (10.45±1.17) ng/ml and (23.96±1.57) ng/L,respectively,while those in the control group were (8.15±1.06) ng/L and (20.70±0.65) ng/L,respectively. There was a statistically significant difference between the two groups (P<0.05).The brain edema volume and NIHSS score in patients with different FOXO1 level and TREM2 level were compared at F_{time point},F_interaction,and F_{among groups}(P<0.05).The brain edema volume and NIHSS score showed a trend of change with time,and there were differences between groups.Higher FOXO1 and TREM2 level group had higher cerebral edema volume at admission,3 days after admission and 5 days after admission,and higher FOXO1 and TREM2 level group had higher scores at 3 days after admission and 5 days after admission (P<0.05).The levels of FOXO1 and TREM2 were positively correlated with cerebral edema volume at admission,3 d and 5 d,and were positively correlated with 3 d and 5 d NIHSS scores at admission (P<0.05).Conclusion Patients with cerebral hemorrhage have abnormal FOXO1 and TREM2 high expression,and FOXO1 and TREM2 levels are significantly positively correlated with brain edema volume and nerve function impairment.

Key words: cerebral hemorrhage;serum forkhead box protein O1;myeloid cell trigger receptor 2;brain edema volume;neural function impairment