Abstract: At present,breast cancer is still the first place in the global incidence and mortality of female cancer.Searching for reliable biological markers plays an extremely important role in clarifying the early diagnosis of breast cancer and improving the long-term survival rate and prognosis of breast cancer patients.In recent years,long non-coding RNA HOTAIR(LncRNA HOTAIR) is still the focus of research by many scholars,and HOTAIR is closely related to the occurrence and development of a variety of malignant tumors.The expression of HOTAIR is particularly obvious in breast cancer patients.More and more studies have shown that HOTAIR is highly expressed in both peripheral blood and breast cancer tissues of breast cancer patients,and is closely related to the proliferation,metastasis and drug resistance of breast cancer.HOTAIR may become an important biomarker for the early diagnosis of breast cancer and a target for breast cancer treatment.

Key words: breast cancer;HOTAIR;early diagnosis