Abstract: Objective To investigate the effect of renal tumor enucleation on renal function,renal parenchyma and teratoma-derived growth factor-1(Cripto-1) in patients with localized renal cell carcinoma. Methods The clinical data of 100 patients with localized renal cell carcinoma who were diagnosed and treated in our hospital from February 2016 to June 2021 were retrospectively analyzed,and then the patients were included in the study group(60 cases) and the control group(40 cases) according to the different treatment options in the data.The study group underwent laparoscopic nephrectomy,and the control group underwent open partial nephrectomy.The operation time,renal artery occlusion time,intraoperative blood loss,hospitalization time,renal function,renal parenchyma and serum Cripto-1 levels before and after the operation were observed and compared.Results The intraoperative blood loss [(89.65±20.22) ml] and hospital stay [(8.25±2.25) d] in the study group were lower than those in the control group [(126.69±25.63) ml,(11.40±3.52)d](P＜0.05).After operation,the levels of GFR,BUN and Scr in the study group were(85.24±2.25) ml/min,(10.47±2.14) mmol/L,and(80.65±10.28) μmol/L,and the levels of GFR,BUN and Scr in the control group were divided into(118.65±3.20) ml/min,(13.41±2.25) mmol/L,(97.45±11.25) μmol/L,and there were significant differences in the levels of GFR,BUN and Scr between the two groups(P＜0.05).After operation,the renal parenchyma volume loss value in the study group [(9.86±2.20) cm3] was lower than that in the control group [(15.96±3.25) cm3](P＜0.05).Three months after operation,the serum Cripto-1 level in the study group [(1.01±0.55)ng/ml] was lower than that in the control group [(2.55±0.85)ng/ml](P＜0.05).Conclusion Renal tumor enucleation can effectively reduce the amount of intraoperative blood loss in patients with localized renal cancer,shorten the time of discharge,and reduce serum Cripto-1 level,while retaining more normal renal parenchyma and improving renal function.

Key words: enucleation of renal tumors, localized renal cell carcinoma, renal function, renal parenchyma, teratoma-derived growth factor-1