Abstract: Objective To explore the open surgical treatment of ureteral stricture after renal transplantation,and to analyze the therapeutic effect and clinical practicability of the operation. Methods The clinical data of 6 patients with ureteral stricture after kidney transplantation admitted to the Department of Organ Transplantation,People’s Hospital of Wuhan University from April 2018 to November 2020 were retrospectively analyzed.All the 6 cases underwent nephrostomy status and ureterovesical replantation.Six patients were followed up after operation. Results The ureteral stenosis occurred 1-76 months postoperatively,with a mean of 16.3 months postoperatively.The serum creatinine（Cr） after kidney transplantation was 100-161 μmol/L,with an average of 119.8 μmol/L.After ureteral stenosis,the Cr of patients was 100-337 μmol/L,with an average of 238.8 μmol/L.All the 6 patients had had their ureteral stents removed within the prescribed time limit before surgery No complications such as transplant hemorrhage and infection occurred during renal graft fistula.Renal function recovered in 6 patients after renal graft fistula,and the postoperative CR was 97-283  μmol/L,with an average of 173.5 μmol/L.All the 6 patients underwent open surgery,and no ureteral mucosal injury occurred during the operation.All the 6 patients were followed up for 3 to 6 months after operation.Now the renal function of the 6 patients has returned to normal level. Conclusion Ureteral stricture is one of the most serious complications after renal transplantation.Open operation has the advantages of obvious therapeutic effect and good postoperative recovery.

Key words: renal transplantation, ureteral stricture, ureter-bladder replantation