Abstract: The prognosis of De novo glomerular diseases and secondary glomerular disease depends on the type of Glomerular Diseases and the degree of disease activity.Renal transplantation is associated with good outcomes in patients with ESRD due to lupus nephritis.The prognosis of patients with amyloidosis after transplantation is related to their hematologic response and the presence of severe cardiac involvement.In patients with antiGBM disease,the recurrence after transplatation is very low and allograft failure from disease recurrence exceedingly rare.However,the patients with serum positive antiGBM were forbidden for transplantation.The prognosis of different subtypes of ANCAassociated vasculitis nephritis is quite variable,the outcome is favorable and transplantation can be performed safely when the patient has achieved clinical remission before transplantation.Simultaneous pancreaskidney transplantation is the preferred treatment for type 1 diabetes patients with endstage renal disease,the management of  diabetes is very critical as well.Patient with renal transplantation in lightchain deposition disease has a high disease recurrence but a low survival rate.However,patients with lightchain deposition disease may still be considered for renal transplantation,but the treatment for recurrence is controversial.De novo MN and IMN can be identified by podocyte HLADR expression and phospholipase A2 receptor staining.FSGS has been reported as the leading form of de novo glomerular disease,The pathogenic factors are various,and the treatment is mainly to remove the persistent effect of the possible pathogenic factors.

Key words: renal transplantation, secondary glomerulonephritis, De novo glomerular diseases, risk factors, treatment, prognosis