Abstract: Objective To analyze the application effect of dexmedetomidine in mixed hemorrhoidectomy under intravenous anesthesia in lateral position.
 Methods 60 patients undergoing mixed hemorrhoidectomy were divided into control group and research group according to random number table method，with 30 cases in each group，and were divided into control group and research group according to random number table method，with 30 cases in each group.Both groups were induced by propofol anesthesia，the control group was maintained by remifentanil and propofol anesthesia，and the study group was maintained by remifentanil and dexmedetomidine anesthesia.The dosage of remifentanil and propofol，anesthesia recovery quality，heart rate（HR），mean arterial pressure（MAP），bispectral index（BIS），visual analogue scale（VAS），and adverse reactions were compared between the two groups.
ResultsThe dosage of propofol and remifentanil in the research group was lesser than that in the control group（P<0.05）.There was no significant difference in respiratory recovery time and awake time between the two groups（P>0.05）.Before anesthesia induction，there was no significant difference in HR，MAP and BIS between the two groups（P>0.05）.HR and MAP in both groups increased 10min after the operation，while BIS in the research group was lower than that in the control group and decreased 10min after the operation，and the research group was lower than that in the control group（P<0.05）.The VAS score of the research group was lower than that of the control group 1 hour and 4 hours after operation（P<0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.
Conclusion Dexmedetomidine on the basis of intravenous anesthesia for mixed hemorrhoid resection does not delay the recovery time of patients and reduces the dosage of narcotic drugs，which can maintain stable hemodynamics and relieve pain，and has high safety.

Key words: dexmedetomidine, lateral position, intravenous anesthesia, excision of mixed hemorrhoids