Abstract: Objective To study the effect of laparoscopic radical prostatectomy on prostate cancer patients and to analyze the effects of TGF- β1，TGF- β3，and PSA levels. Methods From October 2017 to October 2018，104 cases of prostate cancer patients admitted to our hospital were retrospectively analyzed and divided into laparoscopic group and open group according to different treatment methods.Open radical prostatectomy was performed in the open group and laparoscopic radical prostatectomy was performed in the laparoscopic group.Follow-up for 1 year，the survival rate，TGF-β1，TGF-β3 and PSA levels and postoperative complications of the two groups were compared 30 days after surgery，1 day before treatment and 30 days after treatment，respectively. Results The 12-month survival rate of the laparoscopic group was 96.15%（50/52），higher than that of the open group of 84.62%（44/52）（P<0.05）.The serum levels of TGF-β1 and TGF- β3 in the two groups after operation were lower than the before operation（all P<0.05），but the difference between the two groups was not significant（P>0.05）.The serum t-psa and f-psa levels in the two groups after operation were lower than the before operation（all P<0.05），but the difference between the two groups was not significant（P>0.05）.The incidence of postoperative complications in the laparoscopic group was lower than the open group（P<0.05）. Conclusion Laparoscopic radical resection of prostate cancer has a significant effect on patients with prostate cancer，and can effectively improve the levels of TGF- 1，TGF- 3 and PSA，and reduce the risk of postoperative complications.It is worthy of clinical application.

Key words: prostate cancer, laparoscopic radical resection of prostate cancer, transforming growth factor β1, transforming growth factor β3, prostate specific antigen