Abstract: Objective To explore the method and feasibility of individualized and multi-mode management for iatrogenic bile duct injury（IBDI）. Methods From January 2010 to December 2018，22 cases of iatrogenic bile duct injury in general surgery of Panzhihua Group General Hospital of Panzhihua City were retrospectively reviewed.According to the clinical manifestation and injury type of biliary tract injury，the patients were treated with unobstructed external drainage or combined endoscopic biliary duct drainage，biliary plastic repair，choledochojejunostomy，and injury control surgery. Results There were 22 cases of iatrogenic bile duct injury，5 cases were treated with location puncture drainage or external drainage or combined endoscopic drainage，and 9 cases underwent repair of bile duct injury or combined T-tube support drainage.Roux-en-Y choledochojejunostomy was performed in 8 cases，including injury control surgery in 1 case.Overall effective rate 100%. Conclusion Iatrogenic bile duct injury has many types，clinical manifestations are different，or even accompanied by various serious complications.Individualized and multi-mode treatment measures should be taken according to different clinical manifestations and different injury types.

Key words: Iatrogenic bile duct injury, laparoscopic cholecystectomy, cholecystectomy, endoscopic retrograde cholangiopancreatography, cholangiojejunostomy