Abstract: Objective:To investigate the effect of Solifenacin on detrusor function and prognosis in patients with overactive bladder.Methods:128 cases of patients with overactive bladder admitted to our hospital from March 2016 to December 2018 were selected，and 64 cases were divided into control group and research group according to different treatment methods.The control group was treated with trotrodine and the research group with Solifenacin.The clinical efficacy of the two groups was compared and analyzed.Results:The bladder compliance of the study group，the number of bladder compression inhibition，the initial bladder urination，the maximum bladder volume，and the maximum urine flow rate[（53.1±26.4）ml/cm H2O，（1.5±1.2）times，（177.0±88.0）ml，（298.0±88.0）ml，（53.4±17.1）ml/s]was significantly better than the control group[（58.2±29.5）ml/cm H2O，（1.9±1.5）times，（155.0±90.0）ml，（275.0±98.0）ml，（54.0±20.1）ml/s，and the difference was statistically significant（P<0.05）.The OABSS score（5.9±2.4）scores of the study group before and after medication were better than the control group（6.7±3.4），and the difference was statistically significant（P<0.05）.The incidence of adverse events in the study group was 4.6% significantly lower than that in the control group（14.0%），and the difference was statistically significant（P<0.05）.Conclusion:The use of solifenacin for the treatment of OAB patients，the clinical results are satisfactory，the adverse reactions are mild，it is worthy of clinical use.

Key words: Solifenacin, Tolterodine, overactive bladder, detrusor function, adverse reaction