关键词: 肋骨骨折； 术后早期感染； 可溶性人髓系细胞触发受体-1； 基质细胞衍生因子-1； 肿瘤坏死因子-α

Abstract: Objective To explore the value of combined detection of serum soluble human myeloid cell trigger receptor-1 (sTREM-1),stromal cell derived factor-1 (SDF-1) and tumor necrosis factor-α (TNF-α) in predicting the risk of early postoperative infection in patients with rib fracture.Methods A total of 196 patients with rib fractures treated in our hospital from April 2020 to November 2022 were retrospectively selected as the research objects.According to the presence or absence of early postoperative infection,the patients with rib fractures were divided into infected group (n=28) and non-infected group (n=168).The serum levels of sTREM-1,SDF-1 and TNF-α were detected by enzyme-linked immunosorbent assay (ELISA).Multivariate Logistic regression analysis and receiver operating characteristic curve (ROC) were used to evaluate the application value of the three in early postoperative infection of rib fracture.Results The serum sTREM-1 in the infection group and the non-infection group was (115.70±24.93)pg/ml and (82.34±18.83)pg/ml respectively, and the SDF-1 was (220.38±39.86)pg/ml and (175.63±28.59)pg/ml respectively. TNF-α was (58.99±14.78)pg/ml and (40.60±9.89)pg/ml respectively. There was a statistically significant difference between the two groups(all P＜0.05).The AUC of serum sTREM-1,SDF-1 and TNF-α combined prediction was 0.952,which was significantly better than that of the three alone.Conclusion The combined detection of serum sTREM-1,SDF-1,and TNF-α levels has a good predictive effect on early infection after rib fracture surgery.

Key words: rib fracture; early postoperative infection; soluble human myeloid cell trigger receptor-1; stromal cell derived factor-1; tumor necrosis factor-α